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MedKoo Cat#: 208172 | Name: AMT580-043

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AMT580-043, a N-3 alkylated dihydropyrimidin-2(1H)-thione, inhibits the replication of a disease-causing polyomavirus in cell culture more potently than an existing drug, cidofovir.

Chemical Structure

AMT580-043
AMT580-043
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208172

Name: AMT580-043

CAS#: unknown

Chemical Formula: C33H28N6O2S

Exact Mass: 572.1994

Molecular Weight: 572.69

Elemental Analysis: C, 69.21; H, 4.93; N, 14.68; O, 5.59; S, 5.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
AMT580043, AMT580 043, AMT-580-043
IUPAC/Chemical Name
4-Biphenyl-4-yl-6-methyl-3-[4-(1H-tetrazol-5-yl)-benzyl]-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid benzyl ester
InChi Key
OLCMJHPXLBDYIG-UHFFFAOYSA-N
InChi Code
InChI=1S/C33H28N6O2S/c1-22-29(32(40)41-21-24-8-4-2-5-9-24)30(27-18-16-26(17-19-27)25-10-6-3-7-11-25)39(33(42)34-22)20-23-12-14-28(15-13-23)31-35-37-38-36-31/h2-19,30H,20-21H2,1H3,(H,34,42)(H,35,36,37,38)
SMILES Code
O=C(C1=C(C)NC(N(CC2=CC=C(C3=NN=NN3)C=C2)C1C4=CC=C(C5=CC=CC=C5)C=C4)=S)OCC6=CC=CC=C6
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 572.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Manos-Turvey A, Al-Ashtal HA, Needham PG, Hartline CB, Prichard MN, Wipf P, Brodsky JL. Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5087-5091. doi: 10.1016/j.bmcl.2016.08.080. Epub 2016 Aug 25. PMID: 27624078; PMCID: PMC5050167.