MedKoo Cat#: 208152 | Name: Abltide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Abltide-derived sequences are promising substrate-competitive inhibitors for Abl kinase and the T315I mutant.

Chemical Structure

Abltide
Abltide
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208152

Name: Abltide

CAS#: unknown

Chemical Formula: C60H93N15O15

Exact Mass: 1263.6976

Molecular Weight: 1264.49

Elemental Analysis: C, 56.99; H, 7.41; N, 16.62; O, 18.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
abltide
IUPAC/Chemical Name
Lys-Lys-Gly-Glu-Ala-Ile-Tyr-Ala-Ala-Pro-Phe-Ala-NH2
InChi Key
WOEYLBHGXWOZOC-VHCTZGMQSA-N
InChi Code
InChI=1S/C60H93N15O15/c1-7-33(2)49(74-52(82)36(5)67-55(85)43(25-26-48(78)79)70-47(77)32-65-54(84)42(19-12-14-28-62)71-53(83)41(63)18-11-13-27-61)59(89)73-45(31-39-21-23-40(76)24-22-39)57(87)68-35(4)51(81)69-37(6)60(90)75-29-15-20-46(75)58(88)72-44(30-38-16-9-8-10-17-38)56(86)66-34(3)50(64)80/h8-10,16-17,21-24,33-37,41-46,49,76H,7,11-15,18-20,25-32,61-63H2,1-6H3,(H2,64,80)(H,65,84)(H,66,86)(H,67,85)(H,68,87)(H,69,81)(H,70,77)(H,71,83)(H,72,88)(H,73,89)(H,74,82)(H,78,79)/t33-,34-,35-,36-,37-,41-,42-,43-,44-,45-,46-,49-/m0/s1
SMILES Code
O=C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](C)C(N[C@@H](C)C(N2[C@@H](CCC2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,264.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
This message contains search results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM). Do not reply directly to this message Sent On: Thu Jul 28 08:41:08 2022 Search: Abltide 10 selected items PubMed Results Items 1-10 of 10 (Display the 10 citations in PubMed) 1: Huang YH, Henriques ST, Wang CK, Thorstholm L, Daly NL, Kaas Q, Craik DJ. Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Sci Rep. 2015 Aug 12;5:12974. doi: 10.1038/srep12974. PMID: 26264857; PMCID: PMC4532999. 2: Chen H, Adams E, Van Schepdael A. LC-ESI-MS method for the monitoring of Abl 1 tyrosine kinase. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 May 15;897:17-21. doi: 10.1016/j.jchromb.2012.04.001. Epub 2012 Apr 7. PMID: 22538123. 3: Diculescu VC, Enache TA. Electrochemical evaluation of Abelson tyrosine- protein kinase 1 activity and inhibition by imatinib mesylate and danusertib. Anal Chim Acta. 2014 Oct 3;845:23-9. doi: 10.1016/j.aca.2014.06.025. Epub 2014 Jun 17. PMID: 25201268. 4: Wu D, Sylvester JE, Parker LL, Zhou G, Kron SJ. Peptide reporters of kinase activity in whole cell lysates. Biopolymers. 2010;94(4):475-86. doi: 10.1002/bip.21401. PMID: 20593469; PMCID: PMC2914461. 5: Kinoshita-Kikuta E, Aoki Y, Kinoshita E, Koike T. Label-free kinase profiling using phosphate affinity polyacrylamide gel electrophoresis. Mol Cell Proteomics. 2007 Feb;6(2):356-66. doi: 10.1074/mcp.T600044-MCP200. Epub 2006 Nov 5. PMID: 17088264. 6: Chen H, Wang X, Chopra S, Adams E, Van Schepdael A. Development and validation of an indirect pulsed electrochemical detection method for monitoring the inhibition of Abl1 tyrosine kinase. J Pharm Biomed Anal. 2014 Mar;90:52-7. doi: 10.1016/j.jpba.2013.11.022. Epub 2013 Nov 27. PMID: 24333704. 7: Zhou G, Yan X, Wu D, Kron SJ. Photocleavable peptide-conjugated magnetic beads for protein kinase assays by MALDI-TOF MS. Bioconjug Chem. 2010 Oct 20;21(10):1917-24. doi: 10.1021/bc1003058. PMID: 20860375; PMCID: PMC4562279. 8: Cottom J, Hofmann G, Siegfried B, Yang J, Zhang H, Yi T, Ho TF, Quinn C, Wang DY, Johanson K, Ames RS, Li H. Assay development and high-throughput screening of small molecular c-Abl kinase activators. J Biomol Screen. 2011 Jan;16(1):53-64. doi: 10.1177/1087057110384133. Epub 2010 Oct 11. PMID: 20938045. 9: Kondo N, Nishimura S. MALDI-TOF mass-spectrometry-based versatile method for the characterization of protein kinases. Chemistry. 2009;15(6):1413-21. doi: 10.1002/chem.200801650. PMID: 19115309. 10: Chen H, Adams E, Van Schepdael A. Study of Abl1 tyrosine kinase inhibitors by liquid chromatography-electrospray ionization-mass spectrometry. Talanta. 2013 Mar 30;107:88-94. doi: 10.1016/j.talanta.2012.12.046. Epub 2013 Jan 2. PMID: 23598197.