TMX-4100 | CAS#2367619-63-2 | Degrader

MedKoo Cat#: 208146 | Name: TMX-4100

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Exhibit great selectivity for degrading PDE6D and CK1α,

Chemical Structure

TMX-4100

CAS#2367619-63-2

Theoretical Analysis

MedKoo Cat#: 208146

Name: TMX-4100

CAS#: 2367619-63-2

Chemical Formula: C11H10N4O2S

Exact Mass: 262.0524

Molecular Weight: 262.29

Elemental Analysis: C, 50.37; H, 3.84; N, 21.36; O, 12.20; S, 12.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

TMX-4100 , TM-X-4100 , T-MX-4100, TMX4100 , TMX 4100

IUPAC/Chemical Name

3-(4-(Thiophen-3-yl)-1H-1,2,3-triazol-1-yl)piperidine-2,6-dione

InChi Key

PGEUBQZQGXWTFO-UHFFFAOYSA-N

InChi Code

InChI=1S/C11H10N4O2S/c16-10-2-1-9(11(17)12-10)15-5-8(13-14-15)7-3-4-18-6-7/h3-6,9H,1-2H2,(H,12,16,17)

SMILES Code

O=C(C(N1N=NC(C2=CSC=C2)=C1)CC3)NC3=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 262.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Teng M, Lu W, Donovan KA, Sun J, Krupnick NM, Nowak RP, Li YD, Sperling AS, Zhang T, Ebert BL, Fischer ES, Gray NS. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756. doi: 10.1021/acs.jmedchem.1c01832. Epub 2021 Dec 29. PMID: 34965125.