LTURM 34 | CAS#1879887-96-3 | Inhibitor

MedKoo Cat#: 112158 | Name: LTURM 34

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

LTURM 34 is an inhibitor of DNA protein kinase and inhibits the growth of HOP-92, SNB-75, and UO-31 cancer cells.

Chemical Structure

LTURM 34

CAS#1879887-96-3

Theoretical Analysis

MedKoo Cat#: 112158

Name: LTURM 34

CAS#: 1879887-96-3

Chemical Formula: C24H18N2O3S

Exact Mass: 414.1038

Molecular Weight: 414.48

Elemental Analysis: C, 69.55; H, 4.38; N, 6.76; O, 11.58; S, 7.74

Price and Availability

Size	Price	Availability
5mg	USD 295.00	2 Weeks
10mg	USD 560.00	2 Weeks
25mg	USD 950.00	2 Weeks

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Related CAS #

No Data

Synonym

LTURM 34; LTURM34; LTURM-34

IUPAC/Chemical Name

8-(dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-benzo[e][1,3]oxazin-4-one

InChi Key

SMMSWOMXOZLOPI-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H18N2O3S/c27-23-19-9-3-6-16(21(19)29-24(25-23)26-11-13-28-14-12-26)18-8-4-7-17-15-5-1-2-10-20(15)30-22(17)18/h1-10H,11-14H2

SMILES Code

O=C1N=C(OC2=C(C=CC=C21)C3=C4SC5=CC=CC=C5C4=CC=C3)N6CCOCC6

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

LTURM34 is a specific DNA-PK inhibitor (IC50=34 nM).

In vitro activity:

From this series, compound 20k (LTURM34) (dibenzo[b,d]thiophen-4-yl) (IC50 = 0.034 μM) was identified as a specific DNA-PK inhibitor, 170 fold more selective for DNA-PK activity compared to PI3K activity. Reference: Eur J Med Chem. 2016 Mar 3;110:326-39. https://pubmed.ncbi.nlm.nih.gov/26854431/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	5.0	12.06
	DMSO	2.0	4.83

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 414.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Morrison R, Al-Rawi JM, Jennings IG, Thompson PE, Angove MJ. Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur J Med Chem. 2016 Mar 3;110:326-39. doi: 10.1016/j.ejmech.2016.01.042. Epub 2016 Jan 27. PMID: 26854431.

In vitro protocol:

In vivo protocol:

TBD