Synonym
Octatrienoic acid
IUPAC/Chemical Name
2,4,6-Octatrienoic acid, (2E,4E,6E)-
InChi Key
IAAPVNQZSBLWKH-ICDJNDDTSA-N
InChi Code
InChI=1S/C8H10O2/c1-2-3-4-5-6-7-8(9)10/h2-7H,1H3,(H,9,10)/b3-2+,5-4+,7-6+
SMILES Code
C\C=C\C=C\C=C\C(=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
138.17
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Babino G, Caccavale S, Pinto D, Trink A, Giuliani G, Rinaldi F, Argenziano G. A Randomized Double-Blind Parallel-Group Study to Evaluate the Long-Term Effects of a Medical Device Containing 0.3% Octatrienoic Acid in the Treatment of Grade III Actinic Keratosis. Dermatol Ther (Heidelb). 2021 Oct;11(5):1751-1762. doi: 10.1007/s13555-021-00594-w. Epub 2021 Sep 2. PMID: 34476756; PMCID: PMC8484398.
2. Flori E, Mastrofrancesco A, Kovacs D, Bellei B, Briganti S, Maresca V, Cardinali G, Picardo M. The activation of PPARγ by 2,4,6-Octatrienoic acid protects human keratinocytes from UVR-induced damages. Sci Rep. 2017 Aug 23;7(1):9241. doi: 10.1038/s41598-017-09578-3. PMID: 28835664; PMCID: PMC5569026.
3. Pinto D, Trink A, Giuliani G, Rinaldi F. Protective effects of sunscreen (50+) and octatrienoic acid 0.1% in actinic keratosis and UV damages. J Investig Med. 2022 Jan;70(1):92-98. doi: 10.1136/jim-2021-001972. Epub 2021 Sep 16. PMID: 34531252; PMCID: PMC8717479.
4. Lombardi M, Rossi A, Fortuna MC, Garelli V, Sama E, Senis D, Costa C. Treatment of facial actinic keratoses with a cream containing octatrienoic acid: a multicenter clinical experience. G Ital Dermatol Venereol. 2018 Dec;153(6):860-865. doi: 10.23736/S0392-0488.18.06064-9. Epub 2018 Jun 29. PMID: 29963806.
