MedKoo Cat#: 112139 | Name: Nemadipine A
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nemadipine A is an L-type calcium channel blocker.

Chemical Structure

Nemadipine A
Nemadipine A
CAS#54280-71-6

Theoretical Analysis

MedKoo Cat#: 112139

Name: Nemadipine A

CAS#: 54280-71-6

Chemical Formula: C19H18F5NO4

Exact Mass: 419.1156

Molecular Weight: 419.35

Elemental Analysis: C, 54.42; H, 4.33; F, 22.65; N, 3.34; O, 15.26

Price and Availability

Size Price Availability Quantity
5mg USD 260.00 2 Weeks
10mg USD 520.00 2 Weeks
25mg USD 870.00 2 Weeks
50mg USD 1,310.00 2 Weeks
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Related CAS #
No Data
Synonym
Nemadipine A
IUPAC/Chemical Name
diethyl 2,6-dimethyl-4-(perfluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChi Key
QABNLWXKUCMDBP-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H18F5NO4/c1-5-28-18(26)9-7(3)25-8(4)10(19(27)29-6-2)11(9)12-13(20)15(22)17(24)16(23)14(12)21/h11,25H,5-6H2,1-4H3
SMILES Code
FC1=C(C2C(C(OCC)=O)=C(C)NC(C)=C2C(OCC)=O)C(F)=C(F)C(F)=C1F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMSO 20.0 47.69
Ethanol 15.0 35.77
Methanol 100.0 238.46
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 419.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Park SH, Park SJ, Kim JO, Shin JH, Kim ES, Jo YK, Kim JS, Park SJ, Jin DH, Hwang JJ, Lee SJ, Jeong SY, Lee C, Kim I, Cho DH. Down-Regulation of Survivin by Nemadipine-A Sensitizes Cancer Cells to TRAIL-Induced Apoptosis. Biomol Ther (Seoul). 2013 Jan;21(1):29-34. doi: 10.4062/biomolther.2012.088. PMID: 24009855; PMCID: PMC3762295. 2: Li L, Zheng J, Stevens M, Oltean S. A repositioning screen using an FGFR2 splicing reporter reveals compounds that regulate epithelial-mesenchymal transitions and inhibit growth of prostate cancer xenografts. Mol Ther Methods Clin Dev. 2022 Mar 17;25:147-157. doi: 10.1016/j.omtm.2022.03.005. PMID: 35402635; PMCID: PMC8971352. 3: Joyce PI, Satija R, Chen M, Kuwabara PE. The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration. PLoS Genet. 2012;8(3):e1002602. doi: 10.1371/journal.pgen.1002602. Epub 2012 Mar 29. PMID: 22479198; PMCID: PMC3315469.