IUPAC/Chemical Name
(3S,3aR,4S,6aS,12S,15aS,E)-12-hydroxy-3-isobutyl-4,5,8-trimethyl-3,3a,4,6a,9,10,13,14-octahydro-1H-cycloundeca[d]isoindole-1,11,15(2H,12H)-trione
InChi Key
GBCXTRJHTIEBIA-CEXVAXOJSA-N
InChi Code
InChI=1S/C24H35NO4/c1-13(2)10-18-22-16(5)15(4)12-17-11-14(3)6-7-19(26)20(27)8-9-21(28)24(17,22)23(29)25-18/h11-13,16-18,20,22,27H,6-10H2,1-5H3,(H,25,29)/b14-11+/t16-,17+,18+,20+,22+,24-/m1/s1
SMILES Code
C/C1=C\[C@@]2([C@]3([C@@]([H])([C@@H](C(C)=C2)C)[C@@H](NC3=O)CC(C)C)C(CC[C@@H](C(CC1)=O)O)=O)[H]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
401.55
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zhu H, Chen C, Tong Q, Li XN, Yang J, Xue Y, Luo Z, Wang J, Yao G, Zhang Y. Epicochalasines A and B: Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes. Angew Chem Int Ed Engl. 2016 Mar 1;55(10):3486-90. doi: 10.1002/anie.201511315. Epub 2016 Feb 2. PMID: 26836964.
2: Ding G, Chen L, Chen A, Tian X, Chen X, Zhang H, Chen H, Liu XZ, Zhang Y, Zou ZM. Trichalasins C and D from the plant endophytic fungus Trichoderma gamsii. Fitoterapia. 2012 Apr;83(3):541-4. doi: 10.1016/j.fitote.2011.12.021. Epub 2012 Jan 8. PMID: 22245082.
3: Teshima R, Ikebuchi H, Sekita S, Natori S, Terao T. Effects of various cytochalasins on the IgE-mediated serotonin release from rat basophilic leukemia cells. Int Arch Allergy Appl Immunol. 1985;78(3):237-42. doi: 10.1159/000233892. PMID: 2414228.
