NTQ1062 is a Potent and Bioavailable Akt Inhibitor for the Treatment of Human Tumors. NTQ1062 exhibited potent antitumor efficacies in vitro and in vivo, which was accomplished through the optimization of the hinge binder region and the linkage. Subsequent studies of NTQ1062 demonstrated that it possesses good oral pharmacokinetic characteristics and dose-dependent pharmacodynamic effects on downstream biomarkers. In addition, NTQ1062 exhibits a robust antitumor efficacy in xenograft models in which the PI3K-Akt-mTOR pathway was activated.
MedKoo Cat#: 466293
Name: NTQ1062
CAS#: 2459489-66-6
Chemical Formula: C25H31ClN6O2
Exact Mass: 482.2197
Molecular Weight: 483.01
Elemental Analysis: C, 62.17; H, 6.47; Cl, 7.34; N, 17.40; O, 6.62
The following data is based on the product molecular weight 483.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
