SCO-792 | CAS#unknown | Enteropeptidase Inhibitor

MedKoo Cat#: 466291 | Name: SCO-792

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SCO-792 is an Enteropeptidase Inhibitor (IC50=5.4 nM) with Low Systemic Exposure for the Treatment of Obesity. SCO-792 exhibited potent anti-obesity effects despite their low systemic exposure following their oral administration to DIO rats.

Chemical Structure

SCO-792

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 466291

Name: SCO-792

CAS#: unknown

Chemical Formula: C22H22N4O8

Exact Mass: 470.1438

Molecular Weight: 470.44

Elemental Analysis: C, 56.17; H, 4.71; N, 11.91; O, 27.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SCO-792; SCO 792; SCO792;

IUPAC/Chemical Name

(2-((S)-6-((4-guanidinobenzoyl)oxy)-2,3-dihydrobenzofuran-3-yl)acetyl)-L-aspartic acid

InChi Key

PUZUTMLAAWVCCV-ZGTOLYCTSA-N

InChi Code

InChI=1S/C22H22N4O8/c23-22(24)25-13-3-1-11(2-4-13)21(32)34-14-5-6-15-12(10-33-17(15)8-14)7-18(27)26-16(20(30)31)9-19(28)29/h1-6,8,12,16H,7,9-10H2,(H,26,27)(H,28,29)(H,30,31)(H4,23,24,25)/t12-,16?/m1/s1

SMILES Code

NC(NC1=CC=C(C(OC2=CC=C([C@@](CC(N[C@@](CC(O)=O)(C(O)=O)[H])=O)([H])CO3)C3=C2)=O)C=C1)=N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 470.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ikeda Z, Kakegawa K, Kikuchi F, Itono S, Oki H, Yashiro H, Hiyoshi H, Tsuchimori K, Hamagami K, Watanabe M, Sasaki M, Ishihara Y, Tohyama K, Kitazaki T, Maekawa T, Sasaki M. Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity. J Med Chem. 2022 Jun 23;65(12):8456-8477. doi: 10.1021/acs.jmedchem.2c00463. Epub 2022 Jun 10. PMID: 35686954; PMCID: PMC9234964. 2: Rashid MY, Noor A, Patel V, Henin S, Cuello-Ramírez A, Al Kaabi AS, Gnawali A, Mostafa JA. Role of SCO-792, A Novel Enteropeptidase Inhibitor, In the Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis. Cureus. 2021 Mar 5;13(3):e13724. doi: 10.7759/cureus.13724. PMID: 33833935; PMCID: PMC8018875. 3: Katayama Y, Sugama J, Suzuki T, Ishimura Y, Kobayashi A, Moritoh Y, Watanabe M. Enteropeptidase inhibitor SCO-792 effectively prevents kidney function decline and fibrosis in a rat model of chronic kidney disease. Nephrol Dial Transplant. 2021 Mar 29;36(4):631-640. doi: 10.1093/ndt/gfaa349. PMID: 33351150; PMCID: PMC8008362. 4: Sugama J, Moritoh Y, Yashiro H, Tsuchimori K, Watanabe M. Enteropeptidase inhibition improves obesity by modulating gut microbiota composition and enterobacterial metabolites in diet-induced obese mice. Pharmacol Res. 2021 Jan;163:105337. doi: 10.1016/j.phrs.2020.105337. Epub 2020 Dec 1. PMID: 33276106. 5: Sugama J, Katayama Y, Moritoh Y, Watanabe M. Enteropeptidase inhibition improves kidney function in a rat model of diabetic kidney disease. Diabetes Obes Metab. 2021 Jan;23(1):86-96. doi: 10.1111/dom.14190. Epub 2020 Oct 6. PMID: 32893449; PMCID: PMC7756647. 6: Sasaki M, Miyahisa I, Itono S, Yashiro H, Hiyoshi H, Tsuchimori K, Hamagami KI, Moritoh Y, Watanabe M, Tohyama K, Sasaki M, Sakamoto JI, Kawamoto T. Discovery and characterization of a small-molecule enteropeptidase inhibitor, SCO-792. Pharmacol Res Perspect. 2019 Sep 4;7(5):e00517. doi: 10.1002/prp2.517. PMID: 31508234; PMCID: PMC6726858. 7: Yashiro H, Hamagami K, Hiyoshi H, Sugama J, Tsuchimori K, Yamaguchi F, Moritoh Y, Sasaki M, Maekawa T, Yamada Y, Watanabe M. SCO-792, an enteropeptidase inhibitor, improves disease status of diabetes and obesity in mice. Diabetes Obes Metab. 2019 Oct;21(10):2228-2239. doi: 10.1111/dom.13799. Epub 2019 Jul 2. PMID: 31144422; PMCID: PMC6771630.