|
Solvent |
mg/mL |
mM |
| Solubility |
| DMF |
1.0 |
0.81 |
| DMSO |
2.0 |
1.63 |
| PBS (pH:7.2) |
2.0 |
1.63 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
1,229.06
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Williams LK, Zhang X, Caner S, Tysoe C, Nguyen NT, Wicki J, Williams DE, Coleman J, McNeill JH, Yuen V, Andersen RJ, Withers SG, Brayer GD. The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif. Nat Chem Biol. 2015 Sep;11(9):691-6. doi: 10.1038/nchembio.1865. Epub 2015 Jul 27. PMID: 26214255.
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5: Tysoe CR, Caner S, Calvert MB, Win-Mason A, Brayer GD, Withers SG. Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase. Chem Sci. 2019 Oct 18;10(48):11073-11077. doi: 10.1039/c9sc02610j. PMID: 32206255; PMCID: PMC7069248.
6: Irmisch S, Jancsik S, Yuen MMS, Madilao LL, Bohlmann J. Biosynthesis of the anti-diabetic metabolite montbretin A: glucosylation of the central intermediate mini-MbA. Plant J. 2019 Dec;100(5):879-891. doi: 10.1111/tpj.14493. Epub 2019 Sep 16. PMID: 31400245; PMCID: PMC6899944.
7: Maron L. Imitation is the sincerest form of flattery: reconstructing the biosynthesis of montbretin A. Plant J. 2019 Dec;100(5):877-878. doi: 10.1111/tpj.14609. PMID: 31774611.
8: Irmisch S, Ruebsam H, Jancsik S, Man Saint Yuen M, Madilao LL, Bohlmann J. Flavonol Biosynthesis Genes and Their Use in Engineering the Plant Antidiabetic Metabolite Montbretin A. Plant Physiol. 2019 Jul;180(3):1277-1290. doi: 10.1104/pp.19.00254. Epub 2019 Apr 19. PMID: 31004005; PMCID: PMC6752896.
9: Irmisch S, Jo S, Roach CR, Jancsik S, Man Saint Yuen M, Madilao LL, O'Neil- Johnson M, Williams R, Withers SG, Bohlmann J. Discovery of UDP- Glycosyltransferases and BAHD-Acyltransferases Involved in the Biosynthesis of the Antidiabetic Plant Metabolite Montbretin A. Plant Cell. 2018 Aug;30(8):1864-1886. doi: 10.1105/tpc.18.00406. Epub 2018 Jul 2. PMID: 29967287; PMCID: PMC6139687.
