MedKoo Cat#: 208129 | Name: KL-11743
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

KL-11743 is a representative compound that blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate.

Chemical Structure

KL-11743
KL-11743
CAS#1369452-53-8

Theoretical Analysis

MedKoo Cat#: 208129

Name: KL-11743

CAS#: 1369452-53-8

Chemical Formula: C30H30N6O3

Exact Mass: 522.2379

Molecular Weight: 522.61

Elemental Analysis: C, 68.95; H, 5.79; N, 16.08; O, 9.18

Price and Availability

Size Price Availability Quantity
50mg USD 1,650.00 2 Weeks
100mg USD 2,850.00 2 Weeks
200mg USD 4,250.00 2 Weeks
500mg USD 7,650.00 2 Weeks
1g USD 9,850.00 2 Weeks
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Related CAS #
No Data
Synonym
KL-11743; KL 11743; KL11743
IUPAC/Chemical Name
2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-6-ethoxyquinazolin-2-yl)phenoxy)-N-isopropylacetamide
InChi Key
XKOYTLRGOQTKAU-UHFFFAOYSA-N
InChi Code
InChI=1S/C30H30N6O3/c1-4-38-25-12-13-27-26(15-25)30(34-23-10-8-20(9-11-23)22-16-31-32-17-22)36-29(35-27)21-6-5-7-24(14-21)39-18-28(37)33-19(2)3/h5-17,19H,4,18H2,1-3H3,(H,31,32)(H,33,37)(H,34,35,36)
SMILES Code
CC(C)NC(COC1=CC(C2=NC(NC3=CC=C(C4=CNN=C4)C=C3)=C(C=C(OCC)C=C5)C5=N2)=CC=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 522.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Olszewski K, Barsotti A, Feng XJ, Momcilovic M, Liu KG, Kim JI, Morris K, Lamarque C, Gaffney J, Yu X, Patel JP, Rabinowitz JD, Shackelford DB, Poyurovsky MV. Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. Cell Chem Biol. 2022 Mar 17;29(3):423-435.e10. doi: 10.1016/j.chembiol.2021.10.007. Epub 2021 Oct 28. PMID: 34715056.