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MedKoo Cat#: 112084 | Name: Corylifol A
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Corylifol A is a flavonoid which is cytotoxic to (IC50 = 13.5 µg/ml), and inhibits IL-6-induced STAT3 promoter activity in (IC50 = 0.81 µM in a reporter assay), Hep3B hepatocellular carcinoma cells.

Chemical Structure

Corylifol A
CAS#775351-88-7

Theoretical Analysis

MedKoo Cat#: 112084

Name: Corylifol A

CAS#: 775351-88-7

Chemical Formula: C25H26O4

Exact Mass: 390.1831

Molecular Weight: 390.48

Elemental Analysis: C, 76.90; H, 6.71; O, 16.39

Price and Availability

Size Price Availability Quantity
5mg USD 400.00 2 Weeks
10mg USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
Corylifol A; Corylinin
IUPAC/Chemical Name
(E)-3-(3-(3,7-dimethylocta-2,6-dien-1-yl)-4-hydroxyphenyl)-7-hydroxy-4H-chromen-4-one
InChi Key
ZBHUUXLHDOUMKM-REZTVBANSA-N
InChi Code
InChI=1S/C25H26O4/c1-16(2)5-4-6-17(3)7-8-19-13-18(9-12-23(19)27)22-15-29-24-14-20(26)10-11-21(24)25(22)28/h5,7,9-15,26-27H,4,6,8H2,1-3H3/b17-7+
SMILES Code
O=C1C(C2=CC(C/C=C(CC/C=C(C)\C)\C)=C(O)C=C2)=COC3=CC(O)=CC=C31
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
DMF 30.0 76.83
DMSO 30.0 76.83
Ethanol 25.0 64.02
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 390.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Han Y, Lee H, Li H, Ryu JH. Corylifol A from Psoralea corylifolia L. Enhances Myogenesis and Alleviates Muscle Atrophy. Int J Mol Sci. 2020 Feb 25;21(5):1571. doi: 10.3390/ijms21051571. PMID: 32106603; PMCID: PMC7084366. 2: Li N, Miao J, Li J, Zhao YR, Li HM, Dai YQ, Huo Q, Wu CZ, Ma T. Enzymatic synthesis of novel corylifol A glucosides via a UDP-glycosyltransferase. Carbohydr Res. 2017 Jun 29;446-447:61-67. doi: 10.1016/j.carres.2017.05.002. Epub 2017 May 11. PMID: 28528234. 3: Zhang R, Shen Q, Wang Y, Deng X, Fan J, Gu X, Fan M, Wei K, Cheng CR, Zhang WD, Zhang XW, Liu X. Corylifol A ameliorates muscle atrophy by inhibiting TAOK1/p38-MAPK/FoxO3 pathway in cancer cachexia. J Cachexia Sarcopenia Muscle. 2023 Jul 13. doi: 10.1002/jcsm.13288. Epub ahead of print. PMID: 37439183. 4: Xu Y, Song D, Lin X, Peng H, Su Y, Liang J, Hai N, Zhao J, Liu Q. Corylifol A protects against ovariectomized-induced bone loss and attenuates RANKL-induced osteoclastogenesis via ROS reduction, ERK inhibition, and NFATc1 activation. Free Radic Biol Med. 2023 Feb 20;196:121-132. doi: 10.1016/j.freeradbiomed.2023.01.017. Epub 2023 Jan 14. PMID: 36649902. 5: Ouyang L, Fan Z, He Y, Tan L, Deng G, He Q, He Y, Ouyang T, Li C, Zhang Q, Liu H, Zuo Y. 4-hydroxylonchocarpin and corylifol A: The potential hepatotoxic components of Psoralea corylifolia L. Toxicol Lett. 2023 Aug 18:S0378-4274(23)00244-8. doi: 10.1016/j.toxlet.2023.08.008. Epub ahead of print. PMID: 37598872. 6: Yeon MH, Seo E, Lee JH, Jun HS. Bavachin and Corylifol A Improve Muscle Atrophy by Enhancing Mitochondria Quality Control in Type 2 Diabetic Mice. Antioxidants (Basel). 2023 Jan 6;12(1):137. doi: 10.3390/antiox12010137. PMID: 36671000; PMCID: PMC9855061. 7: Li Y, Xu J, Xu C, Qin Z, Li S, Hu L, Yao Z, Gonzalez FJ, Yao X. Metabolism and disposition of corylifol A from Psoralea corylifolia: metabolite mapping, isozyme contribution, species differences and identification of efflux transporters for corylifol A-O-glucuronide in HeLa1A1 cells. Xenobiotica. 2020 Aug;50(8):997-1008. doi: 10.1080/00498254.2020.1732496. Epub 2020 Apr 1. PMID: 32116078; PMCID: PMC7396962. 8: Hou XD, Song LL, Cao YF, Wang YN, Zhou Q, Fang SQ, Wu DC, Zang SZ, Chen L, Bai Y, Ge GB, Hou J. Pancreatic lipase inhibitory constituents from Fructus Psoraleae. Chin J Nat Med. 2020 May;18(5):369-378. doi: 10.1016/S1875-5364(20)30043-1. PMID: 32451094. 9: Du J, Wang CH, Yang J, He X, Han XL, Li CC, Chai X, Wang YF, Zhu Y, Li Z. Chemical constituents from the fruits of Psoralea corylifolia and their protective effects on ionising radiation injury. Nat Prod Res. 2019 Mar;33(5):673-680. doi: 10.1080/14786419.2017.1405407. Epub 2017 Nov 20. PMID: 29156966. 10: Choudhury S, Moulick D, Borah A, Saikia P, Mazumder MK. In search of drugs to alleviate suppression of the host's innate immune responses against SARS- CoV-2 using a molecular modeling approach. In Silico Pharmacol. 2021 Apr 4;9(1):26. doi: 10.1007/s40203-021-00085-y. PMID: 33842190; PMCID: PMC8019474. 11: He L, Chen C, Duan S, Li Y, Li C, Yao X, Gonzalez FJ, Qin Z, Yao Z. Inhibition of estrogen sulfation by Xian-Ling-Gu-Bao capsule. J Steroid Biochem Mol Biol. 2023 Jan;225:106182. doi: 10.1016/j.jsbmb.2022.106182. Epub 2022 Sep 21. PMID: 36152789. 12: Song P, Yang XZ, Yuan JQ. Cytotoxic constituents from Psoralea corylifolia. J Asian Nat Prod Res. 2013;15(6):624-30. doi: 10.1080/10286020.2013.793181. Epub 2013 May 10. PMID: 23659434. 13: Gao Q, Xu Z, Zhao G, Wang H, Weng Z, Pei K, Wu L, Cai B, Chen Z, Li W. Simultaneous quantification of 5 main components of Psoralea corylifolia L. in rats' plasma by utilizing ultra high pressure liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 1;1011:128-35. doi: 10.1016/j.jchromb.2015.12.044. Epub 2015 Dec 30. PMID: 26773881. 14: Swain SS, Sahoo G, Mahapatra PK, Panda SK. Disease Burden and Current Therapeutical Status of Leprosy with Special Emphasis on Phytochemicals. Curr Top Med Chem. 2022;22(19):1611-1625. doi: 10.2174/1568026621666210909162435. PMID: 34503409. 15: Yin FZ, Li L, Lu TL, Li WD, Cai BC, Yin W. Quality Assessment of Psoralea fructus by HPLC Fingerprint Coupled with Multi-components Analysis. Indian J Pharm Sci. 2015 Nov-Dec;77(6):715-22. doi: 10.4103/0250-474x.174996. PMID: 26997699; PMCID: PMC4778231. 16: Xin D, Wang H, Yang J, Su YF, Fan GW, Wang YF, Zhu Y, Gao XM. Phytoestrogens from Psoralea corylifolia reveal estrogen receptor-subtype selectivity. Phytomedicine. 2010 Feb;17(2):126-31. doi: 10.1016/j.phymed.2009.05.015. Epub 2009 Jul 3. PMID: 19577453. 17: He L, Xu C, Wang Z, Duan S, Xu J, Li C, Yao X, Gonzalez FJ, Qin Z, Yao Z. Identification of naturally occurring inhibitors in Xian-Ling-Gu-Bao capsule against the glucuronidation of estrogens. Front Pharmacol. 2022 Aug 4;13:935685. doi: 10.3389/fphar.2022.935685. PMID: 35991901; PMCID: PMC9386001. 18: Zhang Y, Chen Z, Xu X, Zhou Q, Liu X, Liao L, Zhang Z, Wang Z. Rapid separation and simultaneous quantitative determination of 13 constituents in Psoraleae Fructus by a single marker using high-performance liquid chromatography with diode array detection. J Sep Sci. 2017 Nov;40(21):4191-4202. doi: 10.1002/jssc.201700482. Epub 2017 Sep 26. PMID: 28869337. 19: Yan C, Wu Y, Weng Z, Gao Q, Yang G, Chen Z, Cai B, Li W. Development of an HPLC Method for Absolute Quantification and QAMS of Flavonoids Components in Psoralea corylifolia L. J Anal Methods Chem. 2015;2015:792637. doi: 10.1155/2015/792637. Epub 2015 Oct 26. PMID: 26587307; PMCID: PMC4637493. 20: Luan L, Shen X, Liu X, Wu Y, Tan M. Qualitative analysis of Psoraleae Fructus by HPLC-DAD/TOF-MS fingerprint and quantitative analysis of multiple components by single marker. Biomed Chromatogr. 2018 Feb;32(2). doi: 10.1002/bmc.4059. Epub 2017 Sep 14. PMID: 28777876.

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