MedKoo Cat#: 112081 | Name: Carboxyphosphamide
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carboxyphosphamide is an inactive metabolite of the alkylating agent cyclophosphamide.

Chemical Structure

Carboxyphosphamide
Carboxyphosphamide
CAS#22788-18-7

Theoretical Analysis

MedKoo Cat#: 112081

Name: Carboxyphosphamide

CAS#: 22788-18-7

Chemical Formula: C7H15Cl2N2O4P

Exact Mass: 292.0146

Molecular Weight: 293.08

Elemental Analysis: C, 28.69; H, 5.16; Cl, 24.19; N, 9.56; O, 21.84; P, 10.57

Price and Availability

Size Price Availability Quantity
1mg USD 250.00 2 Weeks
5mg USD 450.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Carboxyphosphamide; CPCOOH; NSC 145124; NSC145124; NSC-145124
IUPAC/Chemical Name
3-((amino(bis(2-chloroethyl)amino)phosphoryl)oxy)propanoic acid
InChi Key
QLAKAJLYYGOZQL-UHFFFAOYSA-N
InChi Code
InChI=1S/C7H15Cl2N2O4P/c8-2-4-11(5-3-9)16(10,14)15-6-1-7(12)13/h1-6H2,(H2,10,14)(H,12,13)
SMILES Code
O=C(O)CCOP(N)(N(CCCl)CCCl)=O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 293.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ludeman SM, Ho CK, Boal JH, Sweet EM, Chang YH. Carboxyphosphamide: NMR studies of its stability and cell membrane permeability. Drug Metab Dispos. 1992 Mar-Apr;20(2):337-8. PMID: 1352232. 2: Domeyer BE, Sladek NE. Inhibition by cyanamide of 4-hydroxycyclophosphamide/aldophosphamide oxidation to carboxyphosphamide. Biochem Pharmacol. 1981 Aug 1;30(15):2065-73. doi: 10.1016/0006-2952(81)90224-0. PMID: 7295327. 3: Manthey CL, Sladek NE. Kinetic characterization of the catalysis of "activated" cyclophosphamide (4-hydroxycyclophosphamide/aldophosphamide) oxidation to carboxyphosphamide by mouse hepatic aldehyde dehydrogenases. Biochem Pharmacol. 1988 Jul 15;37(14):2781-90. doi: 10.1016/0006-2952(88)90041-x. PMID: 3395357. 4: Hadidi AH, Coulter CE, Idle JR. Phenotypically deficient urinary elimination of carboxyphosphamide after cyclophosphamide administration to cancer patients. Cancer Res. 1988 Sep 15;48(18):5167-71. PMID: 3409242.