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MedKoo Cat#: 112080 | Name: Incensole Acetate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Incensole acetate is a diterpene that activates transient receptor potential vanilloid 3 (TRPV3). It reduces apoptosis, increases in malondialdehyde (MDA) levels, and the production of reactive oxygen species (ROS) induced by amyloid-β (25-35) peptide in human olfactory bulb neural stem cells (hOBNSCs).

Chemical Structure

Incensole Acetate
Incensole Acetate
CAS#34701-53-6

Theoretical Analysis

MedKoo Cat#: 112080

Name: Incensole Acetate

CAS#: 34701-53-6

Chemical Formula: C22H36O3

Exact Mass: 348.2664

Molecular Weight: 348.53

Elemental Analysis: C, 75.82; H, 10.41; O, 13.77

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
Incensole Acetate; Incensol Acetate
IUPAC/Chemical Name
(1R,2S,5E,9E,12S)-12-isopropyl-1,5,9-trimethyl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl acetate
InChi Key
HVBACKJYWZTKCA-XSLBTUIJSA-N
InChi Code
InChI=1S/C22H36O3/c1-16(2)22-13-12-18(4)9-7-8-17(3)10-11-20(24-19(5)23)21(6,25-22)14-15-22/h8,12,16,20H,7,9-11,13-15H2,1-6H3/b17-8+,18-12+/t20-,21+,22+/m0/s1
SMILES Code
CC(C)[C@]12O[C@]([C@@H](OC(C)=O)CC/C(C)=C/CC/C(C)=C/C2)(C)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMF 25.0 71.73
DMSO 25.0 71.73
Ethanol 25.0 71.73
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 348.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Al-Harrasi A, Csuk R, Khan A, Hussain J. Distribution of the anti- inflammatory and anti-depressant compounds: Incensole and incensole acetate in genus Boswellia. Phytochemistry. 2019 May;161:28-40. doi: 10.1016/j.phytochem.2019.01.007. Epub 2019 Feb 22. PMID: 30802641. 2: Marefati N, Beheshti F, Vafaee F, Barabadi M, Hosseini M. The Effects of Incensole Acetate on Neuro-inflammation, Brain-Derived Neurotrophic Factor and Memory Impairment Induced by Lipopolysaccharide in Rats. Neurochem Res. 2021 Sep;46(9):2473-2484. doi: 10.1007/s11064-021-03381-3. Epub 2021 Jun 26. PMID: 34173963. 3: El-Magd MA, Khalifa SF, A Alzahrani FA, Badawy AA, El-Shetry ES, Dawood LM, Alruwaili MM, Alrawaili HA, Risha EF, El-Taweel FM, Marei HE. Incensole acetate prevents beta-amyloid-induced neurotoxicity in human olfactory bulb neural stem cells. Biomed Pharmacother. 2018 Sep;105:813-823. doi: 10.1016/j.biopha.2018.06.014. Epub 2018 Jun 15. PMID: 29913410. 4: Paul M, Jauch J. Efficient preparation of incensole and incensole acetate, and quantification of these bioactive diterpenes in Boswellia papyrifera by a RP-DAD-HPLC method. Nat Prod Commun. 2012 Mar;7(3):283-8. PMID: 22545396. 5: Moussaieff A, Gross M, Nesher E, Tikhonov T, Yadid G, Pinhasov A. Incensole acetate reduces depressive-like behavior and modulates hippocampal BDNF and CRF expression of submissive animals. J Psychopharmacol. 2012 Dec;26(12):1584-93. doi: 10.1177/0269881112458729. Epub 2012 Sep 26. PMID: 23015543. 6: Moussaieff A, Yu J, Zhu H, Gattoni-Celli S, Shohami E, Kindy MS. Protective effects of incensole acetate on cerebral ischemic injury. Brain Res. 2012 Mar 14;1443:89-97. doi: 10.1016/j.brainres.2012.01.001. Epub 2012 Jan 9. PMID: 22284622; PMCID: PMC3294134. 7: Moussaieff A, Shohami E, Kashman Y, Fride E, Schmitz ML, Renner F, Fiebich BL, Munoz E, Ben-Neriah Y, Mechoulam R. Incensole acetate, a novel anti- inflammatory compound isolated from Boswellia resin, inhibits nuclear factor- kappa B activation. Mol Pharmacol. 2007 Dec;72(6):1657-64. doi: 10.1124/mol.107.038810. Epub 2007 Sep 25. PMID: 17895408. 8: Moussaieff A, Shein NA, Tsenter J, Grigoriadis S, Simeonidou C, Alexandrovich AG, Trembovler V, Ben-Neriah Y, Schmitz ML, Fiebich BL, Munoz E, Mechoulam R, Shohami E. Incensole acetate: a novel neuroprotective agent isolated from Boswellia carterii. J Cereb Blood Flow Metab. 2008 Jul;28(7):1341-52. doi: 10.1038/jcbfm.2008.28. Epub 2008 Apr 16. PMID: 18414499. 9: Moussaieff A, Rimmerman N, Bregman T, Straiker A, Felder CC, Shoham S, Kashman Y, Huang SM, Lee H, Shohami E, Mackie K, Caterina MJ, Walker JM, Fride E, Mechoulam R. Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain. FASEB J. 2008 Aug;22(8):3024-34. doi: 10.1096/fj.07-101865. Epub 2008 May 20. PMID: 18492727; PMCID: PMC2493463.