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MedKoo Cat#: 112076 | Name: Swertisin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Swertisin is a flavonoid C-glycoside that inhibits sodium-glucose cotransporter 2 (SGLT2) and hepatitis B virus (HBV) replication.

Chemical Structure

Swertisin
Swertisin
CAS#6991-10-2

Theoretical Analysis

MedKoo Cat#: 112076

Name: Swertisin

CAS#: 6991-10-2

Chemical Formula: C22H22O10

Exact Mass: 446.1213

Molecular Weight: 446.41

Elemental Analysis: C, 59.19; H, 4.97; O, 35.84

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 750.00 2 Weeks
10mg USD 1,100.00 2 Weeks
25mg USD 1,880.00 2 Weeks
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Related CAS #
No Data
Synonym
Swertisin; NSC 641547; NSC641547; NSC-641547
IUPAC/Chemical Name
5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-6-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-4H-chromen-4-one
InChi Key
ABRULANJVVJLFI-DGHBBABESA-N
InChi Code
InChI=1S/C22H22O10/c1-30-13-7-14-16(11(25)6-12(31-14)9-2-4-10(24)5-3-9)19(27)17(13)22-21(29)20(28)18(26)15(8-23)32-22/h2-7,15,18,20-24,26-29H,8H2,1H3/t15-,18-,20+,21-,22+/m1/s1
SMILES Code
OC1=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=CC(OC)=C1[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 446.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Inhibitory effect of flavonoid glycosides on digestive enzymes: In silico, in vitro, and in vivo studies. Int J Biol Macromol. 2022 Sep 30;217:714-730. doi: 10.1016/j.ijbiomac.2022.07.086. Epub 2022 Jul 14. PMID: 35843397. 15: Liu H, Zhang X, Liu Y, Xin N, Deng Y, Li Y. Semen Ziziphi Spinosae attenuates blood-brain barrier dysfunction induced by lipopolysaccharide by targeting the FAK-DOCK180-Rac1-WAVE2-Arp3 signaling pathway. NPJ Sci Food. 2022 Jun 2;6(1):27. doi: 10.1038/s41538-022-00142-6. PMID: 35655066; PMCID: PMC9163036. 16: Fernandes DC, Martins BP, Silva GPD, Fonseca END, Santos SVM, Velozo LSM, Gayer CRM, Sabino KCC, Coelho MGP. Echinodorus macrophyllus fraction with a high level of flavonoid inhibits peripheral and central mechanisms of nociception. J Tradit Complement Med. 2021 Jul 15;12(2):123-130. doi: 10.1016/j.jtcme.2021.07.001. PMID: 35528477; PMCID: PMC9072821. 17: Zhu Y, Wang W, Liu Z, Jiang S, Tao Y, Jiang L, Mei L. Comprehensive screening and separation of cyclooxygenase-2 inhibitors from Pterocephalus hookeri by affinity solid-phase extraction coupled with preparative high- performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Oct 15;1183:122981. doi: 10.1016/j.jchromb.2021.122981. Epub 2021 Oct 6. PMID: 34634740. 18: Bhardwaj G, Vakani M, Srivastava A, Patel D, Pappachan A, Murumkar P, Shah H, Shah R, Gupta S. Swertisin, a novel SGLT2 inhibitor, with improved glucose homeostasis for effective diabetes therapy. Arch Biochem Biophys. 2021 Oct 15;710:108995. doi: 10.1016/j.abb.2021.108995. Epub 2021 Jul 18. PMID: 34289381. 19: Mahrosh HS, Mustafa G. An in silico approach to target RNA-dependent RNA polymerase of COVID-19 with naturally occurring phytochemicals. Environ Dev Sustain. 2021;23(11):16674-16687. doi: 10.1007/s10668-021-01373-5. Epub 2021 Apr 3. 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