MedKoo Cat#: 208109 | Name: Histidine-proline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Histidine-proline is allosteric inhibitor of ATP phosphoribosyltransferase (ATPPRT).

Chemical Structure

Histidine-proline
Histidine-proline
CAS#20930-58-9

Theoretical Analysis

MedKoo Cat#: 208109

Name: Histidine-proline

CAS#: 20930-58-9

Chemical Formula: C11H16N4O3

Exact Mass: 252.1222

Molecular Weight: 252.27

Elemental Analysis: C, 52.37; H, 6.39; N, 22.21; O, 19.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Histidine-proline; Histidine proline; Histidineproline
IUPAC/Chemical Name
L-histidyl-L-proline
InChi Key
LNCFUHAPNTYMJB-IUCAKERBSA-N
InChi Code
InChI=1S/C11H16N4O3/c12-8(4-7-5-13-6-14-7)10(16)15-3-1-2-9(15)11(17)18/h5-6,8-9H,1-4,12H2,(H,13,14)(H,17,18)/t8-,9-/m0/s1
SMILES Code
OC([C@H]1N(C([C@@H](N)CC2=CNC=N2)=O)CCC1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 252.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Read BJ, Fisher G, Wissett OLR, Machado TFG, Nicholson J, Mitchell JBO, da Silva RG. Allosteric Inhibition of Acinetobacter baumannii ATP Phosphoribosyltransferase by Protein:Dipeptide and Protein:Protein Interactions. ACS Infect Dis. 2022 Jan 14;8(1):197-209. doi: 10.1021/acsinfecdis.1c00539. Epub 2021 Dec 20. PMID: 34928596. 2: Chevilly S, Dolz-Edo L, Martínez-Sánchez G, Morcillo L, Vilagrosa A, López- Nicolás JM, Blanca J, Yenush L, Mulet JM. Distinctive Traits for Drought and Salt Stress Tolerance in Melon (Cucumis melo L.). Front Plant Sci. 2021 Nov 4;12:777060. doi: 10.3389/fpls.2021.777060. PMID: 34804107; PMCID: PMC8600367. 3: Ronca F, Raggi A. Regulation of skeletal muscle AMP deaminase. Carbethoxylation of His-51 belonging to the zinc coordination sphere of the rabbit enzyme promotes its desensitization towards the inhibition by ATP. Biochim Biophys Acta Gen Subj. 2022 Feb;1866(2):130044. doi: 10.1016/j.bbagen.2021.130044. Epub 2021 Oct 25. PMID: 34710488. 4: Heidenreich E, Pfeffer T, Kracke T, Mechtel N, Nawroth P, Hoffmann GF, Schmitt CP, Hell R, Poschet G, Peters V. A Novel UPLC-MS/MS Method Identifies Organ-Specific Dipeptide Profiles. Int J Mol Sci. 2021 Sep 15;22(18):9979. doi: 10.3390/ijms22189979. PMID: 34576148; PMCID: PMC8465603. 5: Migdał W, Kawęcka A, Sikora J, Migdał Ł. Meat Quality of the Native Carpathian Goat Breed in Comparison with the Saanen Breed. Animals (Basel). 2021 Jul 27;11(8):2220. doi: 10.3390/ani11082220. PMID: 34438678; PMCID: PMC8388397. 6: El-Tarabany MS, El-Tarabany AA, Ahmed-Farid OA. Effect of cage density on growth rate, carcass traits, muscle amino acid profile, and antioxidant biomarkers of commercial rabbits. Trop Anim Health Prod. 2021 Jul 9;53(3):393. doi: 10.1007/s11250-021-02842-9. PMID: 34241702. 7: Fang M, Xiong S, Yin T, Hu Y, Liu R, Du H, Liu Y, You J. Proteomic profiling and oxidation site analysis of gaseous ozone oxidized myosin from silver carp (Hypophthalmichthys molitrix) with different oxidation degrees. Food Chem. 2021 Nov 30;363:130307. doi: 10.1016/j.foodchem.2021.130307. Epub 2021 Jun 6. PMID: 34126570. 8: Santoro AM, Zimbone S, Magrì A, La Mendola D, Grasso G. The Role of Copper (II) on Kininogen Binding to Tropomyosin in the Presence of a Histidine-Proline- Rich Peptide. Int J Mol Sci. 2020 Dec 8;21(24):9343. doi: 10.3390/ijms21249343. PMID: 33302425; PMCID: PMC7762548. 9: Tsukano K, Lakritz J, Suzuki K. Plasma amino acid status is useful for understanding intestinal mucosal damage in calves with cryptosporidiosis. Amino Acids. 2020 Oct;52(10):1459-1464. doi: 10.1007/s00726-020-02904-6. Epub 2020 Oct 22. PMID: 33090265. 10: Cadoni G, Giraldi L, Chiarla C, Gervasoni J, Persichilli S, Primiano A, Settimi S, Galli J, Paludetti G, Arzani D, Boccia S, Giovannini I, Almadori G. Prognostic Role of Serum Amino Acids in Head and Neck Cancer. Dis Markers. 2020 Oct 1;2020:2291759. doi: 10.1155/2020/2291759. Erratum in: Dis Markers. 2021 Mar 19;2021:5806367. PMID: 33082883; PMCID: PMC7556086. 11: Verde V, Longo A, Cucci LM, Sanfilippo V, Magrì A, Satriano C, Anfuso CD, Lupo G, La Mendola D. Anti-Angiogenic and Anti-Proliferative Graphene Oxide Nanosheets for Tumor Cell Therapy. Int J Mol Sci. 2020 Aug 4;21(15):5571. doi: 10.3390/ijms21155571. PMID: 32759830; PMCID: PMC7432113. 12: Hussain H, Ziegler J, Mrestani Y, Neubert RHH. Studies of the Corneocytary Pathway Across the Stratum Corneum. Part I: Diffusion of Amino Acids Into the Isolated Corneocytes. Pharmazie. 2019 Jun 1;74(6):340-344. doi: 10.1691/ph.2019.8098. PMID: 31138370. 13: Więch A, Rowińska-Żyrek M, Wątły J, Czarnota A, Hołubowicz R, Szewczuk Z, Ożyhar A, Orłowski M. The intrinsically disordered C-terminal F domain of the ecdysteroid receptor from Aedes aegypti exhibits metal ion-binding ability. J Steroid Biochem Mol Biol. 2019 Feb;186:42-55. doi: 10.1016/j.jsbmb.2018.09.008. Epub 2018 Sep 20. PMID: 30243841. 14: Mahendhar R, Shahbaz A, Riaz M, Aninyei M, Reich DM, Sachmechi I. Effect of Albumin Polymorphism on Thyroid Hormones: A Case Report and Literature Review. Cureus. 2018 Jul 1;10(7):e2903. doi: 10.7759/cureus.2903. PMID: 30197844; PMCID: PMC6126704. 15: Ronca F, Raggi A. Role of the HPRG Component of Striated Muscle AMP Deaminase in the Stability and Cellular Behaviour of the Enzyme. Biomolecules. 2018 Aug 23;8(3):79. doi: 10.3390/biom8030079. PMID: 30142952; PMCID: PMC6164516. 16: Magrì A , Grasso G , Corti F , Finetti F , Greco V , Santoro AM , Sciuto S , La Mendola D , Morbidelli L , Rizzarelli E . Peptides derived from the histidine-proline rich glycoprotein bind copper ions and exhibit anti-angiogenic properties. Dalton Trans. 2018 Jul 17;47(28):9492-9503. doi: 10.1039/c8dt01560k. PMID: 29963662. 17: Sojourner SJ, Graham WM, Whitmore AM, Miles JS, Freeny D, Flores-Rozas H. The Role of HSP40 Conserved Motifs in the Response to Cytotoxic Stress. J Nat Sci. 2018;4(4):e500. PMID: 29682607; PMCID: PMC5906061. 18: Sinduja B, Abraham John S. Sensitive determination of rutin by spectrofluorimetry using carbon dots synthesized from a non-essential amino acid. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Mar 15;193:486-491. doi: 10.1016/j.saa.2017.12.067. Epub 2017 Dec 27. PMID: 29291577. 19: Kragh-Hansen U, Galliano M, Minchiotti L. Clinical, Genetic, and Protein Structural Aspects of Familial Dysalbuminemic Hyperthyroxinemia and Hypertriiodothyroninemia. Front Endocrinol (Lausanne). 2017 Nov 1;8:297. doi: 10.3389/fendo.2017.00297. PMID: 29163366; PMCID: PMC5671950. 20: Weyrauch AK, Jakob M, Schierhorn A, Klösgen RB, Hinderberger D. Purification of rabbit serum histidine-proline-rich glycoprotein via preparative gel electrophoresis and characterization of its glycosylation patterns. PLoS One. 2017 Sep 21;12(9):e0184968. doi: 10.1371/journal.pone.0184968. PMID: 28934288; PMCID: PMC5608300.