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MedKoo Cat#: 208105 | Name: TFGF-18

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TFGF-18 is a semisynthetic GSK-3β inhibitor.

Chemical Structure

TFGF-18
CAS#2222662-20-4

Theoretical Analysis

MedKoo Cat#: 208105

Name: TFGF-18

CAS#: 2222662-20-4

Chemical Formula: C28H30F3NO11

Exact Mass: 613.1771

Molecular Weight: 613.54

Elemental Analysis: C, 54.81; H, 4.93; F, 9.29; N, 2.28; O, 28.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TFGF-18; TFGF 18; TFGF8
IUPAC/Chemical Name
(2S,3S,4R,5R,6S)-6-(2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4-oxo-4H-chromen-6-yl)-3,4,5-trihydroxy-N-((S)-1,1,1-trifluoropropan-2-yl)tetrahydro-2H-pyran-2-carboxamide
InChi Key
YATALNCQFFCOMZ-BZHDNRFDSA-N
InChi Code
InChI=1S/C28H30F3NO11/c1-11(28(29,30)31)32-27(37)26-23(36)21(34)22(35)25(43-26)20-17(40-4)10-18-19(24(20)41-5)13(33)9-15(42-18)12-6-7-14(38-2)16(8-12)39-3/h6-11,21-23,25-26,34-36H,1-5H3,(H,32,37)/t11-,21+,22+,23-,25-,26-/m0/s1
SMILES Code
O[C@@H]1[C@@H](O)[C@H](C2=C(OC)C=C(OC(C3=CC=C(OC)C(OC)=C3)=CC4=O)C4=C2OC)O[C@H](C(N[C@@H](C)C(F)(F)F)=O)[C@H]1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 613.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Xu M, Lantz MJ, Nichols RA, Li QX. Anti-Neuroinflammatory Effects of a Semi-Synthetic Isoorientin-Based Glycogen Synthase Kinase-3β Inhibitor in Lipopolysaccharide-Activated Microglial Cells. ACS Chem Neurosci. 2022 Jan 5;13(1):43-52. doi: 10.1021/acschemneuro.1c00537. Epub 2021 Dec 16. PMID: 34913695.