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MedKoo Cat#: 208094 | Name: SGK1 inhibitor 17a

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SGK1 inhibitor 17a is a highly potent, selective, and bioavailable protein kinase inhibitor for treating osteoarthritis.

Chemical Structure

SGK1 inhibitor 17a
SGK1 inhibitor 17a
CAS#1628048-93-0

Theoretical Analysis

MedKoo Cat#: 208094

Name: SGK1 inhibitor 17a

CAS#: 1628048-93-0

Chemical Formula: C23H21ClFN5O4S

Exact Mass: 517.0987

Molecular Weight: 517.96

Elemental Analysis: C, 53.33; H, 4.09; Cl, 6.84; F, 3.67; N, 13.52; O, 12.36; S, 6.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
SGK1 inhibitor 17a; SGK1inhibitor17a; SGK1-inhibitor-17a
IUPAC/Chemical Name
5-chloro-2-fluoro-N-(4-(4-(((1r,4r)-4-hydroxycyclohexyl)oxy)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)benzenesulfonamide
InChi Key
IKBMUGXVSJZWGW-QAQDUYKDSA-N
InChi Code
InChI=1S/C23H21ClFN5O4S/c24-14-3-10-19(25)20(11-14)35(32,33)30-15-4-1-13(2-5-15)21-27-22-18(12-26-29-22)23(28-21)34-17-8-6-16(31)7-9-17/h1-5,10-12,16-17,30-31H,6-9H2,(H,26,27,28,29)/t16-,17-
SMILES Code
ClC1=CC(S(=O)(NC2=CC=C(C3=NC(NN=C4)=C4C(O[C@H]5CC[C@H](O)CC5)=N3)C=C2)=O)=C(F)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 517.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Halland N, Schmidt F, Weiss T, Li Z, Czech J, Saas J, Ding-Pfennigdorff D, Dreyer MK, Strübing C, Nazare M. Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis. J Med Chem. 2022 Jan 27;65(2):1567-1584. doi: 10.1021/acs.jmedchem.1c01601. Epub 2021 Dec 21. PMID: 34931844. 2. Du YN, Tang XF, Xu L, Chen WD, Gao PJ, Han WQ. SGK1-FoxO1 Signaling Pathway Mediates Th17/Treg Imbalance and Target Organ Inflammation in Angiotensin II-Induced Hypertension. Front Physiol. 2018 Nov 15;9:1581. doi: 10.3389/fphys.2018.01581. PMID: 30524295; PMCID: PMC6262360.