Corydine | CAS#476-69-7 | Inhibitor

MedKoo Cat#: 112050 | Name: Corydine

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Corydine is an aporphine alkaloid and inhibits the proliferation of murine L1210 lymphocytic leukemia, B16/F10 melanoma, and P388 leukemia cells when used at concentrations ranging from 10 to 100 µg/ml.

Chemical Structure

Corydine

CAS#476-69-7

Theoretical Analysis

MedKoo Cat#: 112050

Name: Corydine

CAS#: 476-69-7

Chemical Formula: C20H23NO4

Exact Mass: 341.1627

Molecular Weight: 341.41

Elemental Analysis: C, 70.36; H, 6.79; N, 4.10; O, 18.74

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 350.00	2 Weeks
5mg	USD 985.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

(+)-Corydine; (+)Corydine; (+) Corydine; Corydine; Glaucentrin; Glaucentrine

IUPAC/Chemical Name

(S)-2,10,11-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol

InChi Key

IDQUPXZJURZAGF-ZDUSSCGKSA-N

InChi Code

InChI=1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)19(22)18-16(12)13(21)9-11-5-6-14(23-2)20(25-4)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1

SMILES Code

OC1=C2C3=C(CCN([C@]3(CC4=CC=C(C(OC)=C42)OC)[H])C)C=C1OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 341.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Shafiee A, Jafarabadi AH. Corydine and norcorydine from the roots of Chelidonium majus. Planta Med. 1998 Jun;64(5):489. doi: 10.1055/s-2006-957498. PMID: 17253273. 2: Kaserer T, Steinacher T, Kainhofer R, Erli F, Sturm S, Waltenberger B, Schuster D, Spetea M. Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists. Sci Rep. 2020 Aug 14;10(1):13804. doi: 10.1038/s41598-020-70493-1. PMID: 32796875; PMCID: PMC7427800. 3: Kondo Y, Imai Y, Hojo H, Endo T, Nozoe S. Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine. J Pharmacobiodyn. 1990 Jul;13(7):426-31. doi: 10.1248/bpb1978.13.426. PMID: 2290126. 4: Gerecke M, Borer R, Brossi A. Selective ther cleavage in the aporphine series. Conversion of (S)-bulbocapnine into (S)-corytuberine and (S)-corydine methyl ether. Helv Chim Acta. 1976 Nov 3;59(7):2551-7. doi: 10.1002/hlca.19760590731. PMID: 14090. 5: Kiryakov HG, Iskrenova E, Daskalova E, Kuzmanov B, Evstatieva L. Alkaloids of Corydalis slivenensis. Planta Med. 1982 Mar;44(3):168-70. doi: 10.1055/s-2007-971432. PMID: 17402105. 6: Debray M, Plat M, Le Men J. Alcaloïdes des Ménispermacées africaines. II. Stephania dinklagei (Engl.) Diels: isolement de la (plus) corydine, de la (plus) isocorydine et de la (minus) roemérine [Alkaloids of African Menispermaceae. II. Stephania dinklagei (Engl.) Diels: isolation of (plus) corydine, (plus) isocorydine and (minus) roemerine]. Ann Pharm Fr. 1967 Mar;25(3):237-42. French. PMID: 5611531. 7: Parvin MS, Chlebek J, Hošťálková A, Catapano MC, Lomozová Z, Macáková K, Mladěnka P. Interactions of Isoquinoline Alkaloids with Transition Metals Iron and Copper. Molecules. 2022 Sep 29;27(19):6429. doi: 10.3390/molecules27196429. PMID: 36234964; PMCID: PMC9572997. 8: Ablajan N, Zhao B, Wenjuan X, Zhao J, Sagdullaev SS, Guoan Z, Aisa HA. Chemical components of Aconitum barbatum var. puberulum and their cytotoxic and antibacterial activities. Nat Prod Res. 2023 Apr;37(8):1382-1385. doi: 10.1080/14786419.2021.2005050. Epub 2021 Nov 22. PMID: 34802347. 9: Adsersen A, Kjølbye A, Dall O, Jäger AK. Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava Schweigg. & Kort. J Ethnopharmacol. 2007 Aug 15;113(1):179-82. doi: 10.1016/j.jep.2007.05.006. Epub 2007 May 6. PMID: 17574358. 10: Kiryakov HG, Iskrenova E, Kuzmanov B, Evstatieva L. Alkaloids from Corydalis marschalliana. Planta Med. 1981 Mar;41(3):298-302. doi: 10.1055/s-2007-971718. PMID: 17401850. 11: Kiryakov HG, Iskrenova E, Kuzmanov B, Evstatieva L. Alkaloids from Corydalis bulbosa. Planta Med. 1981 Sep;43(1):51-5. doi: 10.1055/s-2007-971472. PMID: 17402008. 12: Hu R, Dai X, Lu Y, Pan Y. Preparative separation of isoquinoline alkaloids from Stephania yunnanensis by pH-zone-refining counter-current chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jul 1;878(21):1881-4. doi: 10.1016/j.jchromb.2010.05.005. Epub 2010 May 9. PMID: 20570221. 13: Gören AC, Zhou BN, Kingston DG. Cytotoxic and DNA damaging activity of some aporphine alkaloids from Stephania dinklagei. Planta Med. 2003 Sep;69(9):867-8. doi: 10.1055/s-2003-43224. PMID: 14598219. 14: He SM, Song WL, Cong K, Wang X, Dong Y, Cai J, Zhang JJ, Zhang GH, Yang JL, Yang SC, Fan W. Identification of candidate genes involved in isoquinoline alkaloids biosynthesis in Dactylicapnos scandens by transcriptome analysis. Sci Rep. 2017 Aug 22;7(1):9119. doi: 10.1038/s41598-017-08672-w. PMID: 28831066; PMCID: PMC5567367. 15: Camacho MR, Kirby GC, Warhurst DC, Croft SL, Phillipson JD. Oxoaporphine alkaloids and quinones from Stephania dinklagei and evaluation of their antiprotozoal activities. Planta Med. 2000 Jun;66(5):478-80. doi: 10.1055/s-2000-8597. PMID: 10909274. 16: Husna Hasnan MH, Sivasothy Y, Khaw KY, Nafiah MA, Hazni H, Litaudon M, Wan Ruzali WA, Liew SY, Awang K. N-Methyl Costaricine and Costaricine, Two Potent Butyrylcholinesterase Inhibitors from Alseodaphne pendulifolia Gamb. Int J Mol Sci. 2023 Jun 27;24(13):10699. doi: 10.3390/ijms241310699. PMID: 37445877; PMCID: PMC10341795. 17: Dai X, Hu R, Sun C, Pan Y. Comprehensive separation and analysis of alkaloids from Stephania yunnanensis by counter-current chromatography coupled with liquid chromatography tandem mass spectrometry analysis. J Chromatogr A. 2012 Feb 24;1226:18-23. doi: 10.1016/j.chroma.2011.10.022. Epub 2011 Oct 14. PMID: 22041142. 18: Gözler T. Alkaloids of Turkish Glaucium species. Planta Med. 1982 Nov;46(3):179-80. doi: 10.1055/s-2007-971209. PMID: 17396968. 19: Chen Y, Li M, Liu J, Yan Q, Zhong M, Liu J, Di D, Liu J. Simultaneous determination of the content of isoquinoline alkaloids in Dicranostigma leptopodum (Maxim) Fedde and the effective fractionation of the alkaloids by high-performance liquid chromatography with diode array detection. J Sep Sci. 2015 Jan;38(1):9-17. doi: 10.1002/jssc.201400905. Epub 2014 Nov 19. PMID: 25330407. 20: Zhang M, Liang G, Yu J, Pan W. Aporphine alkaloids from the roots of Stephania viridiflavens. Nat Prod Res. 2010 Aug;24(13):1243-7. doi: 10.1080/14786410903125393. PMID: 20645211.