MedKoo Cat#: 578361 | Name: NS-3956 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NS-3956 free base is a partial nAChR α4β2 LS and HS agonist with analgesic properties.

Chemical Structure

NS-3956 free base
NS-3956 free base
CAS#223796-90-5

Theoretical Analysis

MedKoo Cat#: 578361

Name: NS-3956 free base

CAS#: 223796-90-5

Chemical Formula: C10H14ClN3

Exact Mass: 211.0876

Molecular Weight: 211.69

Elemental Analysis: C, 56.74; H, 6.67; Cl, 16.75; N, 19.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NS-3956 free base; NS 3956 free base; NS3956 free base
IUPAC/Chemical Name
1H-1,4-Diazepine, 1-(5-chloro-3-pyridinyl)hexahydro-
InChi Key
LYMBELAAKZROPC-UHFFFAOYSA-N
InChi Code
1S/C10H14ClN3/c11-9-6-10(8-13-7-9)14-4-1-2-12-3-5-14/h6-8,12H,1-5H2
SMILES Code
Clc1cncc(c1)N2CCCNCC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 211.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Rode F, Munro G, Holst D, Nielsen EØ, Troelsen KB, Timmermann DB, Rønn LC, Grunnet M. Positive allosteric modulation of α4β2 nAChR agonist induced behaviour. Brain Res. 2012 Jun 6;1458:67-75. doi: 10.1016/j.brainres.2012.03.064. Epub 2012 Apr 4. PMID: 22552114. 2. Andreasen JT, Nielsen EØ, Christensen JK, Olsen GM, Peters D, Mirza NR, Redrobe JP. Subtype-selective nicotinic acetylcholine receptor agonists enhance the responsiveness to citalopram and reboxetine in the mouse forced swim test. J Psychopharmacol. 2011 Oct;25(10):1347-56. doi: 10.1177/0269881110364271. Epub 2010 Apr 1. PMID: 20360159.