MedKoo Cat#: 208084 | Name: MZ58

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MZ58 is a novel PD-1/PD-L1 interaction inhibitor, revealing antitumor effects.

Chemical Structure

MZ58
MZ58
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208084

Name: MZ58

CAS#: N/A

Chemical Formula: C44H35NO6

Exact Mass: 673.2464

Molecular Weight: 673.77

Elemental Analysis: C, 78.44; H, 5.24; N, 2.08; O, 14.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
MZ58; M Z58; MZ-58; M Z58; M-Z58
IUPAC/Chemical Name
(R)-2-(4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)-2-((2-oxo-2H-benzo[h]chromen-4-yl)oxy)benzyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
InChi Key
MFFDDZVOAONRQG-LDLOPFEMSA-N
InChi Code
InChI=1S/C44H35NO6/c1-28-34(15-9-17-36(28)29-10-3-2-4-11-29)27-49-35-20-18-33(26-45-25-32-14-6-5-13-31(32)22-39(45)44(47)48)40(23-35)50-41-24-42(46)51-43-37-16-8-7-12-30(37)19-21-38(41)43/h2-21,23-24,39H,22,25-27H2,1H3,(H,47,48)/t39-/m1/s1
SMILES Code
OC([C@H](N(CC1=CC=C(OCC2=C(C)C(C3=CC=CC=C3)=CC=C2)C=C1OC(C(C=CC4=C5C=CC=C4)=C5O6)=CC6=O)C7)CC8=C7C=CC=C8)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 673.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Zhang M, Liu J, Wang Y, Wang P, Morris-Natschke S, Lee KH. Molecular hybridization used to design and synthesize neo-tanshinlactone derivatives as PD-1/PD-L1 inhibitors. Bioorg Med Chem. 2022 Jan 15;54:116579. doi: 10.1016/j.bmc.2021.116579. Epub 2021 Dec 16. PMID: 34954618. 2. Madden LV, Ellis MA, Lalancette N, Hughes G, Wilson LL. Evaluation of a Disease Warning System for Downy Mildew of Grapes. Plant Dis. 2000 May;84(5):549-554. doi: 10.1094/PDIS.2000.84.5.549. PMID: 30841347. 3. Iizuka M, Kaga E, Chiba M, Masamune O, Gerna G, Nakagomi O. Serotype G6 human rotavirus sharing a conserved genetic constellation with natural reassortants between members of the bovine and AU-1 genogroups. Arch Virol. 1994;135(3-4):427-32. doi: 10.1007/BF01310026. PMID: 7979978. 4. Iizuka M, Chiba M, Masamune O, Gerna G, Nakagomi O. Molecular characterization of human rotavirus VP4 genes by polymerase chain reaction and restriction fragment length polymorphism assay. Microbiol Immunol. 1993;37(9):729-35. doi: 10.1111/j.1348-0421.1993.tb01698.x. Erratum in: Microbiol Immunol. 1993;37(11):915. PMID: 7903789. 5. Gerna G, Sarasini A, Di Matteo A, Zentilin L, Miranda P, Parea M, Baldanti F, Arista S, Milanesi G, Battaglia M. Serotype 3 human rotavirus strains with subgroup I specificity. J Clin Microbiol. 1990 Jun;28(6):1342-7. doi: 10.1128/jcm.28.6.1342-1347.1990. PMID: 2166081; PMCID: PMC267930.