MedKoo Cat#: 112039 | Name: N-desmethyl Asenapine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

N-desmethyl Asenapine is a metabolite of the atypical antipsychotic (±)-asenapine. Asenapine is used to treat schizophrenia and acute mania associated with bipolar 1 disorder.

Chemical Structure

N-desmethyl Asenapine
N-desmethyl Asenapine
CAS#128915-56-0

Theoretical Analysis

MedKoo Cat#: 112039

Name: N-desmethyl Asenapine

CAS#: 128915-56-0

Chemical Formula: C16H14ClNO

Exact Mass: 271.0764

Molecular Weight: 271.74

Elemental Analysis: C, 70.72; H, 5.19; Cl, 13.05; N, 5.15; O, 5.89

Price and Availability

Size Price Availability Quantity
1mg USD 305.00 2 Weeks
5mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
DMA; ORG 30526; ORG-30526; ORG30526; N desmethyl Asenapine; N-desmethyl Asenapine
IUPAC/Chemical Name
(3aS,12bS)-5-chloro-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
InChi Key
DQUCRGAOGUQHJQ-ZIAGYGMSSA-N
InChi Code
InChI=1S/C16H14ClNO/c17-10-5-6-16-12(7-10)14-9-18-8-13(14)11-3-1-2-4-15(11)19-16/h1-7,13-14,18H,8-9H2/t13-,14-/m1/s1
SMILES Code
ClC1=CC=C2OC3=CC=CC=C3[C@@]4([H])CNC[C@@]4(C2=C1)[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 271.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gerrits MG, de Greef R, Dogterom P, Peeters PA. Valproate reduces the glucuronidation of asenapine without affecting asenapine plasma concentrations. J Clin Pharmacol. 2012 May;52(5):757-65. doi: 10.1177/0091270011404028. Epub 2011 May 31. PMID: 21628604. 2: Peeters P, Bockbrader H, Spaans E, Dogterom P, Lasseter K, Marbury T, Gibson GL, de Greef R. Asenapine pharmacokinetics in hepatic and renal impairment. Clin Pharmacokinet. 2011 Jul;50(7):471-81. doi: 10.2165/11590490-000000000-00000. PMID: 21651314. 3: Patel NP, Sanyal M, Sharma N, Patel DS, Shrivastav PS, Patel BN. Determination of asenapine in presence of its inactive metabolites in human plasma by LC-MS/MS. J Pharm Anal. 2018 Oct;8(5):341-347. doi: 10.1016/j.jpha.2018.06.002. Epub 2018 Jun 18. PMID: 30345149; PMCID: PMC6190535.