dTAG-47 is a degrader targeting mutant FKBP12F36V fusion proteins. It comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a cereblon-binding ligand. Application of dTAG-47 induces rapid, reversible and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo. dTAG-47 is generalizable to a range of fusion proteins. It is useful as an alternative to genetic methods for target validation.
MedKoo Cat#: 466259
Name: dTAG-47
CAS#: 2265886-81-3
Chemical Formula: C59H73N5O14
Exact Mass: 1075.5154
Molecular Weight: 1076.25
Elemental Analysis: C, 65.84; H, 6.84; N, 6.51; O, 20.81
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 107.6 | 100.00 |
The following data is based on the product molecular weight 1,076.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
