MedKoo Cat#: 208076 | Name: MTPDDS

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MTPDDS is a mitochondrial protein-linked DNA that breaks perturb mitochondrial gene transcription and triggers free radical-induced DNA damage.

Chemical Structure

MTPDDS
MTPDDS
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208076

Name: MTPDDS

CAS#: N/A

Chemical Formula: C61H60BrN4O14P

Exact Mass: 1182.3027

Molecular Weight: 1184.04

Elemental Analysis: C, 61.88; H, 5.11; Br, 6.75; N, 4.73; O, 18.92; P, 2.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MTPDDS
IUPAC/Chemical Name
(4-(4-((3-hydroxy-4-((E)-3-(((2R,3R,4R,6S)-3-hydroxy-2-methyl-6-(((1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)amino)-3-oxoprop-1-en-1-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)butyl)triphenylphosphonium bromide
InChi Key
FTPYNKSALNZZDW-RFHWTXLMSA-N
InChi Code
InChI=1S/C61H59N4O14P.BrH/c1-36-56(70)45(30-51(78-36)79-48-32-61(75,49(68)34-66)31-44-53(48)60(74)55-54(58(44)72)57(71)43-21-14-22-47(76-2)52(43)59(55)73)62-50(69)26-24-37-23-25-39(29-46(37)67)77-35-38-33-65(64-63-38)27-12-13-28-80(40-15-6-3-7-16-40,41-17-8-4-9-18-41)42-19-10-5-11-20-42;/h3-11,14-26,29,33,36,45,48,51,56,66,70,75H,12-13,27-28,30-32,34-35H2,1-2H3,(H3-,62,63,64,67,69,71,72,73,74);1H/t36-,45-,48+,51-,56+,61+;/m1./s1
SMILES Code
COC1=CC=CC(C(C2=C3C(O)=C4C(C[C@@](O)(C(CO)=O)C[C@@H]4O[C@H]5O[C@H](C)[C@H](O)[C@H](NC(/C=C/C6=C(O)C=C(OCC7=CN(CCCC[P+](C8=CC=CC=C8)(C9=CC=CC=C9)C%10=CC=CC=C%10)N=N7)C=C6)=O)C5)=C2O)=O)=C1C3=O.[Br-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,184.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Chiang SC, Meagher M, Kassouf N, Hafezparast M, McKinnon PJ, Haywood R, El-Khamisy SF. Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage. Sci Adv. 2017 Apr 28;3(4):e1602506. doi: 10.1126/sciadv.1602506. PMID: 28508041; PMCID: PMC5409496.