Ralmitaront (RO6889450) is a trace amine-associated receptor 1 (TAAR1) partial agonist being investigated for its potential antipsychotic effects. Preclinical studies have demonstrated that Ralmitaront modulates dopaminergic and glutamatergic neurotransmission, which may contribute to its antipsychotic-like activity. In vitro, it shows high selectivity for TAAR1 with submicromolar potency (EC₅₀ ~100 nM) and partial agonist efficacy. In vivo studies suggest it can reduce hyperlocomotion induced by dopaminergic stimulants, indicative of antipsychotic potential.
MedKoo Cat#: 208072
Name: Ralmitaront free base
CAS#: 2133417-13-5
Chemical Formula: C17H22N4O2
Exact Mass: 314.1743
Molecular Weight: 314.39
Elemental Analysis: C, 64.95; H, 7.05; N, 17.82; O, 10.18
The following data is based on the product molecular weight 314.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
