MedKoo Cat#: 578289 | Name: Norcholic acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Norcholic acid is a biochemical found in the urine of patients with liver cirrhosis. Norcholic acid has been shown to promote tumor progression in Hepatocellular Carcinoma by regulating Farnesoid X receptor (FXR).

Chemical Structure

Norcholic acid
Norcholic acid
CAS#60696-62-0

Theoretical Analysis

MedKoo Cat#: 578289

Name: Norcholic acid

CAS#: 60696-62-0

Chemical Formula: C23H38O5

Exact Mass: 394.2719

Molecular Weight: 394.55

Elemental Analysis: C, 70.02; H, 9.71; O, 20.27

Price and Availability

Size Price Availability Quantity
10mg USD 240.00 2 Weeks
50mg USD 560.00 2 Weeks
100mg USD 870.00 2 Weeks
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Related CAS #
No Data
Synonym
Norcholic acid; Norcholate
IUPAC/Chemical Name
24-Norcholan-23-oic acid, 3,7,12-trihydroxy-, (3alpha,5beta,7alpha,12alpha)-
InChi Key
SHUYNJFEXPRUGR-RTCCEZQESA-N
InChi Code
InChI=1S/C23H38O5/c1-12(8-20(27)28)15-4-5-16-21-17(11-19(26)23(15,16)3)22(2)7-6-14(24)9-13(22)10-18(21)25/h12-19,21,24-26H,4-11H2,1-3H3,(H,27,28)/t12-,13+,14-,15-,16+,17+,18-,19+,21+,22+,23-/m1/s1
SMILES Code
C[C@H](CC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 394.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Gong Y, Li K, Qin Y, Zeng K, Liu J, Huang S, Chen Y, Yu H, Liu W, Ye L, Yang Y. Norcholic Acid Promotes Tumor Progression and Immune Escape by Regulating Farnesoid X Receptor in Hepatocellular Carcinoma. Front Oncol. 2021 Nov 23;11:711448. doi: 10.3389/fonc.2021.711448. PMID: 34888230; PMCID: PMC8648605. 2. Nakatomi F, Kihira K, Kuramoto T, Hoshita T. Intestinal absorption and metabolism of norcholic acid in rats. J Pharmacobiodyn. 1985 Jul;8(7):557-63. doi: 10.1248/bpb1978.8.557. PMID: 4067817.