ELOVL1 inhibitor 22 | CAS# | Novel inhibitor

MedKoo Cat#: 208065 | Name: ELOVL1 inhibitor 22

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ELOVL1 inhibitor 22 is a novel, orally bioavailable pyrimidine ether-based inhibitor.

Chemical Structure

ELOVL1 inhibitor 22

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208065

Name: ELOVL1 inhibitor 22

CAS#: N/A

Chemical Formula: C21H23N5O2

Exact Mass: 377.1852

Molecular Weight: 377.45

Elemental Analysis: C, 66.83; H, 6.14; N, 18.55; O, 8.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ELOVL1 inhibitor 22; ELOVL1-inhibitor-22; ELOVL1inhibitor22; ELOVL1inhibitor 22; ELOVL1 inhibitor22

IUPAC/Chemical Name

(2R)-4-(6-(3-(1H-pyrazol-1-yl)cyclobutoxy)pyrimidin-4-yl)-2-phenylmorpholine

InChi Key

JXGFJBHPOCYADP-MNNMKWMVSA-N

InChi Code

InChI=1S/C21H23N5O2/c1-2-5-16(6-3-1)19-14-25(9-10-27-19)20-13-21(23-15-22-20)28-18-11-17(12-18)26-8-4-7-24-26/h1-8,13,15,17-19H,9-12,14H2/t17?,18-,19-/m0/s1

SMILES Code

C1([C@H]2OCCN(C3=NC=NC(O[C@@H]4CC(N5N=CC=C5)C4)=C3)C2)=CC=CC=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 377.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Boyd MJ, Collier PN, Clark MP, Deng H, Kesavan S, Ronkin SM, Waal N, Wang J, Cao J, Li P, Come J, Davies I, Duffy JP, Cochran JE, Court JJ, Chandupatla K, Jackson KL, Maltais F, O'Dowd H, Boucher C, Considine T, Taylor WP, Gao H, Chakilam A, Engtrakul J, Crawford D, Doyle E, Phillips J, Kemper R, Swett R, Empfield J, Bunnage ME, Charifson PS, Magavi SS. Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1. J Med Chem. 2021 Dec 23;64(24):17777-17794. doi: 10.1021/acs.jmedchem.1c00948. Epub 2021 Dec 6. PMID: 34871500.