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MedKoo Cat#: 208047 | Name: MS170

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MS170 is a novel and potent AKT proteolysis targeting chimera (PROTAC) cereblon (CRBN)-recruiting degrader.

Chemical Structure

MS170
MS170
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208047

Name: MS170

CAS#: N/A

Chemical Formula: C45H56ClN9O7

Exact Mass: 869.3991

Molecular Weight: 870.45

Elemental Analysis: C, 62.09; H, 6.48; Cl, 4.07; N, 14.48; O, 12.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MS170; MS 170; MS-170
IUPAC/Chemical Name
3-(((S)-2-(4-chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)propanamide
InChi Key
QMLFGZYEQAMKRK-SCQVZNLVSA-N
InChi Code
InChI=1S/C45H56ClN9O7/c1-28-25-35(56)40-38(28)41(51-27-50-40)53-21-23-54(24-22-53)43(60)32(29-11-13-30(46)14-12-29)26-47-20-17-36(57)49-19-7-5-3-2-4-6-18-48-33-10-8-9-31-39(33)45(62)55(44(31)61)34-15-16-37(58)52-42(34)59/h8-14,27-28,32,34-35,47-48,56H,2-7,15-26H2,1H3,(H,49,57)(H,52,58,59)/t28-,32-,34?,35-/m1/s1
SMILES Code
O=C(NCCCCCCCCNC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)CCNC[C@H](C4=CC=C(Cl)C=C4)C(N5CCN(C6=C7C([C@H](O)C[C@H]7C)=NC=N6)CC5)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 870.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Yu X, Xu J, Xie L, Wang L, Shen Y, Cahuzac KM, Chen X, Liu J, Parsons RE, Jin J. Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders. J Med Chem. 2021 Dec 23;64(24):18054-18081. doi: 10.1021/acs.jmedchem.1c01476. Epub 2021 Dec 2. PMID: 34855399; PMCID: PMC8819633. 2. Stevison LS, Kohn MH. Divergence population genetic analysis of hybridization between rhesus and cynomolgus macaques. Mol Ecol. 2009 Jun;18(11):2457-75. doi: 10.1111/j.1365-294X.2009.04212.x. PMID: 19457196. 3. Fortunato A, Strassmann JE, Santorelli L, Queller DC. Co-occurrence in nature of different clones of the social amoeba, Dictyostelium discoideum. Mol Ecol. 2003 Apr;12(4):1031-8. doi: 10.1046/j.1365-294x.2003.01792.x. PMID: 12753221.