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MedKoo Cat#: 578246 | Name: NNC-22-0215

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NNC-22-0215 is a metabolically stable dopamine D1 antagonist.

Chemical Structure

NNC-22-0215
NNC-22-0215
CAS#152125-09-2

Theoretical Analysis

MedKoo Cat#: 578246

Name: NNC-22-0215

CAS#: 152125-09-2

Chemical Formula: C19H18Cl3NO2

Exact Mass: 397.0403

Molecular Weight: 398.71

Elemental Analysis: C, 57.24; H, 4.55; Cl, 26.67; N, 3.51; O, 8.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NNC-22-0215; NNC 22-0215; NNC22-0215
IUPAC/Chemical Name
(+)-7-Chloro-1-(5,6-dichloro-2,3-dihydrobenzofuran-7-yl)-8-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
InChi Key
XTBPVXNRDRWQNN-ZDUSSCGKSA-N
InChi Code
1S/C19H18Cl3NO2/c1-23-4-2-10-6-14(20)16(24)8-12(10)13(9-23)17-18(22)15(21)7-11-3-5-25-19(11)17/h6-8,13,24H,2-5,9H2,1H3/t13-/m0/s1
SMILES Code
CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3c(Cl)c(Cl)cc4CCOc34
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 398.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Foged C, Halldin C, Swahn CG, Ginovart N, Karlsson P, Lundkvist C, Farde L. [11C]NNC 22-0215, a metabolically stable dopamine D1 radioligand for PET. Nucl Med Biol. 1998 Jul;25(5):503-8. doi: 10.1016/s0969-8051(98)00010-9. PMID: 9720669. 2. Casey DE. The effects of D1 (NNC 22-0215) and D2 (haloperidol) antagonists in a chronic double-blind placebo controlled trial in cebus monkeys. Psychopharmacology (Berl). 1995 Oct;121(3):289-93. doi: 10.1007/BF02246065. PMID: 8584608.

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