Neurounina-1 | CAS# | NCX activator

MedKoo Cat#: 208040 | Name: Neurounina-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Neurounina-1 is a novel unique NCX activator, modulating the Na+/Ca2+ exchanger Isoforms.

Chemical Structure

Neurounina-1

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208040

Name: Neurounina-1

CAS#: N/A

Chemical Formula: C20H20N4O3

Exact Mass: 364.1535

Molecular Weight: 364.41

Elemental Analysis: C, 65.92; H, 5.53; N, 15.38; O, 13.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Neurounina-1; Neurounina 1; Neurounina1

IUPAC/Chemical Name

7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

InChi Key

CUVPPONHRDLGFB-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H20N4O3/c25-19-13-21-20(15-6-2-1-3-7-15)17-12-16(24(26)27)8-9-18(17)23(19)14-22-10-4-5-11-22/h1-3,6-9,12H,4-5,10-11,13-14H2

SMILES Code

O=C1N(CN2CCCC2)C3=C(C=C([N+]([O-])=O)C=C3)C(C4=CC=CC=C4)=NC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 364.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Magli E, Fattorusso C, Persico M, Corvino A, Esposito G, Fiorino F, Luciano P, Perissutti E, Santagada V, Severino B, Tedeschi V, Pannaccione A, Pignataro G, Caliendo G, Annunziato L, Secondo A, Frecentese F. New Insights into the Structure-Activity Relationship and Neuroprotective Profile of Benzodiazepinone Derivatives of Neurounina-1 as Modulators of the Na+/Ca2+ Exchanger Isoforms. J Med Chem. 2021 Dec 23;64(24):17901-17919. doi: 10.1021/acs.jmedchem.1c01212. Epub 2021 Nov 30. PMID: 34845907; PMCID: PMC8713167. 2: Anzilotti S, Valsecchi V, Brancaccio P, Guida N, Laudati G, Tedeschi V, Petrozziello T, Frecentese F, Magli E, Hassler B, Cuomo O, Formisano L, Secondo A, Annunziato L, Pignataro G. Prolonged NCX activation prevents SOD1 accumulation, reduces neuroinflammation, ameliorates motor behavior and prolongs survival in a ALS mouse model. Neurobiol Dis. 2021 Nov;159:105480. doi: 10.1016/j.nbd.2021.105480. Epub 2021 Aug 16. PMID: 34411705. 3: Severino B, Corvino A, Fiorino F, Frecentese F, Perissutti E, Caliendo G, Santagada V, Magli E, Molinaro P, Pignataro G, Annunziato L, Antunes NJ, Rojas- Moscoso J, de Freitas NL, Mendes GD, De Nucci G. Development, Validation of LC- MS/MS Method and Determination of Pharmacokinetic Parameters of the Stroke Neuroprotectant Neurounina-1 in Beagle Dog Plasma After Intravenous Administration. Front Pharmacol. 2019 Apr 25;10:432. doi: 10.3389/fphar.2019.00432. PMID: 31073288; PMCID: PMC6497007. 4: Cerullo P, Brancaccio P, Anzilotti S, Vinciguerra A, Cuomo O, Fiorino F, Severino B, Di Vaio P, Di Renzo G, Annunziato L, Pignataro G. Acute and long- term NCX activation reduces brain injury and restores behavioral functions in mice subjected to neonatal brain ischemia. Neuropharmacology. 2018 Jun;135:180-191. doi: 10.1016/j.neuropharm.2018.03.017. Epub 2018 Mar 15. PMID: 29551690. 5: Molinaro P, Cantile M, Cuomo O, Secondo A, Pannaccione A, Ambrosino P, Pignataro G, Fiorino F, Severino B, Gatta E, Sisalli MJ, Milanese M, Scorziello A, Bonanno G, Robello M, Santagada V, Caliendo G, Di Renzo G, Annunziato L. Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage. Mol Pharmacol. 2013 Jan;83(1):142-56. doi: 10.1124/mol.112.080986. Epub 2012 Oct 11. PMID: 23066092.