NM-135 | CAS# 169453-84-3 | Biochemical

MedKoo Cat#: 578239 | Name: NM-135

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NM-135 is a prodrug glucocorticoid with anti-inflammatory activity.

Chemical Structure

NM-135

CAS#169453-84-3

Theoretical Analysis

MedKoo Cat#: 578239

Name: NM-135

CAS#: 169453-84-3

Chemical Formula: C60H62F2O13

Exact Mass: 1028.4158

Molecular Weight: 1029.14

Elemental Analysis: C, 70.03; H, 6.07; F, 3.69; O, 20.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

NM-135; NM 135; NM135

IUPAC/Chemical Name

Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11-hydroxy-16-methyl-21-((2,3,4,6-tetrakis-O-(4-methylbenzoyl)-beta-D-glucopyranosyl)oxy)-, (6alpha,11beta,16alpha)-

InChi Key

BVEAZFTXNPWHMR-QBKHVOGRSA-N

InChi Code

1S/C60H62F2O13/c1-32-8-16-37(17-9-32)53(66)70-31-47-50(73-54(67)38-18-10-33(2)11-19-38)51(74-55(68)39-20-12-34(3)13-21-39)52(75-56(69)40-22-14-35(4)15-23-40)57(72-47)71-30-46(64)49-36(5)26-42-43-28-45(61)44-27-41(63)24-25-59(44,7)60(43,62)48(65)29-58(42,49)6/h8-25,27,36,42-43,45,47-52,57,65H,26,28-31H2,1-7H3/t36-,42+,43+,45+,47-,48+,49-,50-,51+,52-,57-,58+,59+,60+/m1/s1

SMILES Code

C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO[C@@H]5O[C@H](COC(=O)c6ccc(C)cc6)[C@@H](OC(=O)c7ccc(C)cc7)[C@H](OC(=O)c8ccc(C)cc8)[C@H]5OC(=O)c9ccc(C)cc9

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,029.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Ishii T, Kibushi N, Nakajima T, Kakuta T, Tanaka N, Sato C, Sugai K, Kijima-Suda I, Kai H, Miyata T. Local anti-inflammatory activity and systemic side effects of NM-135, a new prodrug glucocorticoid, in an experimental inflammatory rat model. Jpn J Pharmacol. 1998 Dec;78(4):505-9. doi: 10.1254/jjp.78.505. PMID: 9920209.