MedKoo Cat#: 208032 | Name: VU6015241

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU6015241 is a novel potent and selective antagonist of the M4 Muscarinic Acetylcholine receptor.

Chemical Structure

VU6015241
VU6015241
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208032

Name: VU6015241

CAS#: N/A

Chemical Formula: C26H35N5O2

Exact Mass: 449.2791

Molecular Weight: 449.60

Elemental Analysis: C, 69.46; H, 7.85; N, 15.58; O, 7.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
VU6015241; VU-6015241; VU6015241
IUPAC/Chemical Name
(R)-N-(4-(6-(((6-((tetrahydro-2H-pyran-4-yl)methyl)-6-azaspiro[2.5]octan-1-yl)methyl)amino)pyridazin-3-yl)phenyl)acetamide
InChi Key
ZIJBOKSMUUIGCK-QFIPXVFZSA-N
InChi Code
InChI=1S/C26H35N5O2/c1-19(32)28-23-4-2-21(3-5-23)24-6-7-25(30-29-24)27-17-22-16-26(22)10-12-31(13-11-26)18-20-8-14-33-15-9-20/h2-7,20,22H,8-18H2,1H3,(H,27,30)(H,28,32)/t22-/m0/s1
SMILES Code
CC(NC1=CC=C(C2=CC=C(NC[C@H]3C4(CCN(CC5CCOCC5)CC4)C3)N=N2)C=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 449.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Bender AM, Carter TR, Spock M, Rodriguez AL, Dickerson JW, Rook JM, Chang S, Qi A, Presley CC, Engers DW, Harp JM, Bridges TM, Niswender CM, Conn PJ, Lindsley CW. Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor. Bioorg Med Chem Lett. 2022 Jan 15;56:128479. doi: 10.1016/j.bmcl.2021.128479. Epub 2021 Nov 24. PMID: 34838649.