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MedKoo Cat#: 208021 | Name: AA147
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AA147 is a novel proteostasis regulator, protecting against glutamate-induced cell death in a neuronal-derived cell culture model, activating transcription factor 6 (ATF6) arm of the unfolded protein response and the NRF2-regulated oxidative stress response. AA147 restored neurological function and reduced dead neurons in mice suffering from cardiac arrest (CA). Moreover, AA147 inhibited CA/CPR-caused neuronal apoptosis and ER stress. The expression of ATF6 and its regulated gene glucose-regulated protein 78 (GRP78) increased significantly after the administration of AA147, suggesting the activation of the ATF6 pathway. In addition, AA147 also alleviated the upsurge of the ROS generation and MDA levels as well as increased SOD activity, accompanied by enhancement of the nuclear factor E2-related factor 2 (Nrf2) and its modulated heme-oxygenase-1 (HO-1) expressions.

Chemical Structure

AA147
AA147
CAS#393121-74-9

Theoretical Analysis

MedKoo Cat#: 208021

Name: AA147

CAS#: 393121-74-9

Chemical Formula: C16H17NO2

Exact Mass: 255.1259

Molecular Weight: 255.32

Elemental Analysis: C, 75.27; H, 6.71; N, 5.49; O, 12.53

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
AA147; AA 147; AA-147; ATF6 activator 147; ATF6-activator 147; ATF6 activator-147
IUPAC/Chemical Name
N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
InChi Key
AWHLTHOHBAGPMY-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H17NO2/c1-12-7-9-15(18)14(11-12)17-16(19)10-8-13-5-3-2-4-6-13/h2-7,9,11,18H,8,10H2,1H3,(H,17,19)
SMILES Code
O=C(CCC1=CC=CC=C1)NC2=CC(C)=CC=C2O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 255.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yuan Z, Lu L, Lian Y, Zhao Y, Tang T, Xu S, Yao Z, Yu Z. AA147 ameliorates post-cardiac arrest cerebral ischemia/reperfusion injury through the co- regulation of the ATF6 and Nrf2 signaling pathways. Front Pharmacol. 2022 Nov 23;13:1028002. doi: 10.3389/fphar.2022.1028002. PMID: 36506549; PMCID: PMC9727236. 2: Rosarda JD, Baron KR, Nutsch K, Kline GM, Stanton C, Kelly JW, Bollong MJ, Wiseman RL. Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. ACS Chem Biol. 2021 Dec 17;16(12):2852-2863. doi: 10.1021/acschembio.1c00810. Epub 2021 Nov 19. PMID: 34797633; PMCID: PMC8689639. 3: Kubra KT, Akhter MS, Saini Y, Kousoulas KG, Barabutis N. Activating transcription factor 6 protects against endothelial barrier dysfunction. Cell Signal. 2022 Nov;99:110432. doi: 10.1016/j.cellsig.2022.110432. Epub 2022 Aug 4. PMID: 35933031. 4: Kline GM, Paxman RJ, Lin CY, Madrazo N, Grandjean JM, Lee K, Nugroho K, Powers ET, Wiseman RL, Kelly JW. Divergent Proteome Reactivity Influences Arm- Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators. bioRxiv [Preprint]. 2023 Jan 17:2023.01.16.524237. doi: 10.1101/2023.01.16.524237. PMID: 36712115; PMCID: PMC9882204. 5: Li B, Yang H, Wu H, Wang H, Ye Z, Wu Y, Chen Y, Tang H. Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 May 6. doi: 10.1002/tox.23814. Epub ahead of print. PMID: 37148176. 6: Tang T, Lian Y, Lu L, Xu S, Yu Z. [Crosstalk between activating transcription factor 6 and the inositol-requiring enzyme 1-X-box binding protein 1 pathway in oxygen-glucose deprivation/reoxygenation-injured HT22 cells]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2023 Mar;35(3):278-286. Chinese. doi: 10.3760/cma.j.cn121430-20230228-00115. PMID: 36916341. 7: Yamamoto V, Wang B, Lee AS. Suppression of head and neck cancer cell survival and cisplatin resistance by GRP78 small molecule inhibitor YUM70. Front Oncol. 2023 Jan 11;12:1044699. doi: 10.3389/fonc.2022.1044699. PMID: 36713577; PMCID: PMC9875086. 8: Grandjean JMD, Wiseman RL. Small molecule strategies to harness the unfolded protein response: where do we go from here? J Biol Chem. 2020 Nov 13;295(46):15692-15711. doi: 10.1074/jbc.REV120.010218. Epub 2020 Sep 4. PMID: 32887796; PMCID: PMC7667976. 9: Ji YP, Zhao LY, Zhou B, Zhong ML, Zhuang J, Yuan Q. [Investigation and analysis of occult hepatitis B virus infection among voluntary blood donors in Lishui area]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011 Dec;25(6):457-9. Chinese. PMID: 22734235. 10: Wang M, Cotter E, Wang YJ, Fu X, Whittsette AL, Lynch JW, Wiseman RL, Kelly JW, Keramidas A, Mu TW. Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors. Cell Biosci. 2022 Apr 27;12(1):48. doi: 10.1186/s13578-022-00783-w. PMID: 35477478; PMCID: PMC9044816. 11: Chen CR, Yuan Q, Ge SX, Ou SH, Ni HY, Zhang YC, Pei B, Li A, Yan Q, Lin YC, Chen QR, Xia NS, Zhang J. [Surveillance for occult HBV infection and HBsAg variants in blood donors]. Bing Du Xue Bao. 2009 May;25(3):178-84. Chinese. PMID: 19634759. 12: Sun S, Wang C, Zhao P, Kline GM, Grandjean JMD, Jiang X, Labaudiniere R, Wiseman RL, Kelly JW, Balch WE. Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis. Cell Chem Biol. 2023 Jan 19;30(1):22-42.e5. doi: 10.1016/j.chembiol.2022.12.004. Epub 2023 Jan 10. PMID: 36630963; PMCID: PMC9930901. 13: Cheng N, Shi JH, Jin Y, Shi YB, Liu XD, Zhang HP, Cao SL, Yang H, Guo WZ, Zhang SJ. Pharmacological Activating Transcription Factor 6 Activation Is Beneficial for Liver Retrieval With ex vivo Normothermic Mechanical Perfusion From Cardiac Dead Donor Rats. Front Surg. 2021 Jun 18;8:665260. doi: 10.3389/fsurg.2021.665260. PMID: 34222317; PMCID: PMC8249577.