NIP-121 | CAS# 135244-62-1 | Biochemical

MedKoo Cat#: 578193 | Name: NIP-121

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NIP-121 is a vasodilator with antihypertensive properties.

Chemical Structure

NIP-121

CAS#135244-62-1

Theoretical Analysis

MedKoo Cat#: 578193

Name: NIP-121

CAS#: 135244-62-1

Chemical Formula: C16H19N3O4

Exact Mass: 317.1376

Molecular Weight: 317.34

Elemental Analysis: C, 60.56; H, 6.04; N, 13.24; O, 20.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

NIP-121; NIP 121; NIP121

IUPAC/Chemical Name

2-Piperidinone, 1-(7,8-dihydro-7-hydroxy-6,6-dimethyl-6H-pyrano(2,3-f)-2,1,3-benzoxadiazol-8-yl)-, trans-(+)-

InChi Key

KMXPHBJUGYLXDM-LSDHHAIUSA-N

InChi Code

InChI=1S/C16H19N3O4/c1-16(2)15(21)14(19-6-4-3-5-13(19)20)9-7-10-11(18-23-17-10)8-12(9)22-16/h7-8,14-15,21H,3-6H2,1-2H3/t14-,15+/m0/s1

SMILES Code

CC1(C)Oc2cc3nonc3cc2[C@@H]([C@H]1O)N4CCCCC4=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 317.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Oka M, Morris KG, McMurtry IF. NIP-121 is more effective than nifedipine in acutely reversing chronic pulmonary hypertension. J Appl Physiol (1985). 1993 Sep;75(3):1075-80. doi: 10.1152/jappl.1993.75.3.1075. PMID: 8226514. 2. Masuda Y, Arakawa C, Yokoyama T, Shigenobu K, Tanaka S. The antihypertensive property of NIP-121, a novel potassium channel opener in rats. J Cardiovasc Pharmacol. 1991 Aug;18(2):190-7. doi: 10.1097/00005344-199108000-00003. PMID: 1717778. 3. Tanaka H, Okazaki K, Shigenobu K. Cardioprotective effects of NIP-121, a novel ATP-sensitive potassium channel opener, during ischemia and reperfusion in coronary perfused guinea pig myocardium. J Cardiovasc Pharmacol. 1996 May;27(5):695-701. doi: 10.1097/00005344-199605000-00012. PMID: 8859940.