Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude.
MedKoo Cat#: 466248
Name: Covidcil-19
CAS#: 1225177-95-6
Chemical Formula: C16H14N4O2
Exact Mass: 294.1117
Molecular Weight: 294.31
Elemental Analysis: C, 65.30; H, 4.79; N, 19.04; O, 10.87
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| To be determined | 2.9 | 10.00 |
The following data is based on the product molecular weight 294.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
