Synonym
Nivimedone sodium monohydrate; Nivimedone sodium hydrate
IUPAC/Chemical Name
sodium (5,6-dimethyl-1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)azinate hydrate
InChi Key
CCVFYFVABDKJST-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H8NO4.Na.H2O/c1-5-3-7-8(4-6(5)2)11(14)9(10(7)13)12(15)16;;/h3-4H,1-2H3;;1H2/q-1;+1;
SMILES Code
O.[Na+].Cc1cc2C(=O)C(=N(=O)[O-])C(=O)c2cc1C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
259.19
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lumb EM, McHardy GJ, Kay AB. The orally administered anti-allergic agent, sodium nivimedone (BRL 10833); efficacy in bronchial asthma and effects on IgE, complement and eosinophils. Br J Clin Pharmacol. 1979 Jul;8(1):65-74. doi: 10.1111/j.1365-2125.1979.tb05911.x. PMID: 121884; PMCID: PMC1429720.
2: Spicer BA, Ross JW, Sharpe TJ, Smith H. Peritoneal anaphylaxis in the rat after sensitization with mouse antiserum. Int Arch Allergy Appl Immunol. 1978;56(6):493-9. doi: 10.1159/000232064. PMID: 415988.
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4: Ross JW, Smith H, Spicer BA. Increased vascular permeability during passive peritoneal anaphylaxis in the rat. The effects of disodium cromoglycate and a nitroindanedione. Int Arch Allergy Appl Immunol. 1976;51(2):226-37. doi: 10.1159/000231595. PMID: 58838.
5: Sharpe TJ, Smith H. Effects of drugs on the acute inflammation following intraperitoneal injection of antigen into actively sensitised rats. Int Arch Allergy Appl Immunol. 1979;60(2):216-21. doi: 10.1159/000232344. PMID: 89095.
6: González R, Arruzazabala ML, Sarracent J. Effects of antiallergic drugs on cyclic nucleotides in guinea pig ileum and trachea. Allergol Immunopathol (Madr). 1987 Nov-Dec;15(6):361-3. PMID: 2833089.
7: Sharpe TJ, Ross JW, Spicer BA. The effect of sodium 5,6-dimethyl-2-nitroindanedione on anaphylactic reactions in vitro. Agents Actions. 1978 Apr;8(3):199-202. doi: 10.1007/BF01966603. PMID: 78665.
8: Browne JT, Smyth WF. Polarographic behaviour and analysis of 2-nitro-5,6-dimethylindane-1,3-dione in raw materials and pharmaceutical formulations. Analyst. 1980 Jan;105(1246):25-9. doi: 10.1039/an9800500025. PMID: 7386887.
9: Pauwels R, Lamont H, Van der Straeten M. The inhibition of allergen induced bronchospasm in man by oral BRL 10833. Clin Allergy. 1976 Sep;6(5):471-8. doi: 10.1111/j.1365-2222.1976.tb01931.x. PMID: 824069.
10: Arruzazabala ML, Casacó A, González R, de la Vega AR. Efecto de varias drogas profilácticas antiasmáticas sobre la broncoconstricción inducida por keroseno en conejos [Effect of several antiasthmatic prophylactic drugs on bronchoconstriction induced by kerosene in rabbits]. Allergol Immunopathol (Madr). 1983 Nov-Dec;11(6):421-4. Spanish. PMID: 6422727.
