Synonym
Nivacortol; Nivazol; Win27,914; Win-27,914; Win 27,914
IUPAC/Chemical Name
(1R,3aS,3bR,10aR,10bS,12aS)-1-ethynyl-7-(4-fluorophenyl)-10a,12a-dimethyl-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazol-1-ol
InChi Key
ZQLOAGFNRKBEAJ-BDPSOKNUSA-N
InChi Code
InChI=1S/C28H31FN2O/c1-4-28(32)14-12-24-22-10-5-19-15-25-18(16-26(19,2)23(22)11-13-27(24,28)3)17-30-31(25)21-8-6-20(29)7-9-21/h1,6-9,15,17,22-24,32H,5,10-14,16H2,2-3H3/t22-,23+,24+,26+,27+,28+/m1/s1
SMILES Code
C[C@]12Cc3cnn(c3C=C1CC[C@@H]4[C@@H]2CC[C@@]5(C)[C@H]4CC[C@@]5(O)C#C)c6ccc(F)cc6
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
430.57
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Adams EF, Ashby MJ, Burrin J, Yeo TH, Drucker R, Stringer K, Mashiter K. Effect of nivazol on ACTH secretion by human pituitary corticotrophic tumours in cell culture. Clin Endocrinol (Oxf). 1985 May;22(5):631-8. doi: 10.1111/j.1365-2265.1985.tb02999.x. PMID: 2992847.
2. Schane HP, Harding HR, Creange JE, Botton I, Castracane VD, Snyder BW. Nivazol: a glucocorticoid in rats with only hypothalamic-pituitary-adrenal-inhibiting activity in primates. Endocrinology. 1984 Jun;114(6):1983-9. doi: 10.1210/endo-114-6-1983. PMID: 6723571.
3. Winneker RC, Russell MM, Might CK, Schane HP. The interaction of nivazol with the glucocorticoid receptor from rat and rhesus monkey target tissues. Steroids. 1984 Nov;44(5):447-57. doi: 10.1016/s0039-128x(84)80004-5. PMID: 6549568.
4. Spence CD, Coghlan JP, Denton DA, Mills EH, Whitworth JA, Scoggins BA. The effect of nivazol and cortivazol, novel synthetic steroids containing a phenylpyrazolo A-ring substitution, on blood pressure in sheep. J Steroid Biochem. 1986 Sep;25(3):411-5. doi: 10.1016/0022-4731(86)90254-2. PMID: 3773516.
