Synonym
SDZ-224015; SDZ224015; SDZ 224015;
IUPAC/Chemical Name
ethyl (5S,6R,12S)-12-(2-((2,6-dichlorobenzoyl)oxy)acetyl)-6-isopropyl-5-methyl-3,7,10-trioxo-1-phenyl-2-oxa-4,8,11-triazatetradecan-14-oate
InChi Key
NTWVFYCDXRVJCY-HLULCQHTSA-N
InChi Code
InChI=1S/C31H37Cl2N3O9/c1-5-43-26(39)14-23(24(37)17-44-30(41)28-21(32)12-9-13-22(28)33)36-25(38)15-34-29(40)27(18(2)3)19(4)35-31(42)45-16-20-10-7-6-8-11-20/h6-13,18-19,23,27H,5,14-17H2,1-4H3,(H,34,40)(H,35,42)(H,36,38)/t19-,23-,27+/m0/s1
SMILES Code
O=C([C@@H](NC(CNC([C@@H]([C@H](C)NC(OCC1=CC=CC=C1)=O)C(C)C)=O)=O)CC(OCC)=O)COC(C2=C(C=CC=C2Cl)Cl)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
666.55
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Redhead MA, Owen CD, Brewitz L, Collette AH, Lukacik P, Strain-Damerell C, Robinson SW, Collins PM, Schäfer P, Swindells M, Radoux CJ, Hopkins IN, Fearon D, Douangamath A, von Delft F, Malla TR, Vangeel L, Vercruysse T, Thibaut J, Leyssen P, Nguyen TT, Hull M, Tumber A, Hallett DJ, Schofield CJ, Stuart DI, Hopkins AL, Walsh MA. Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19. Sci Rep. 2021 Jun 24;11(1):13208. doi: 10.1038/s41598-021-92416-4. Erratum in: Sci Rep. 2021 Sep 28;11(1):19633. PMID: 34168183; PMCID: PMC8225628.
2: Elford PR, Heng R, Révész L, MacKenzie AR. Reduction of inflammation and pyrexia in the rat by oral administration of SDZ 224-015, an inhibitor of the interleukin-1 beta converting enzyme. Br J Pharmacol. 1995 Jun;115(4):601-6. doi: 10.1111/j.1476-5381.1995.tb14974.x. PMID: 7582478; PMCID: PMC1908483.
