MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 466227 | Name: RV-568

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RV-568 is a p38 MAPK inhibitor clinically evaluated for pulmonary diseases.

Chemical Structure

RV-568
RV-568
CAS#1220626-82-3

Theoretical Analysis

MedKoo Cat#: 466227

Name: RV-568

CAS#: 1220626-82-3

Chemical Formula: C34H36N6O4

Exact Mass: 592.2798

Molecular Weight: 592.70

Elemental Analysis: C, 68.90; H, 6.12; N, 14.18; O, 10.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
RV-568; RV568; RV 568; JNJ-49095397; I92MU0V408; 1220626-82-3
IUPAC/Chemical Name
N-(4-(((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)methyl)pyridin-2-yl)-2-methoxyacetamide
InChi Key
RTDCVLCTBQDLBW-UHFFFAOYSA-N
InChi Code
InChI=1S/C34H36N6O4/c1-22-10-12-24(13-11-22)40-31(19-29(39-40)34(2,3)4)38-33(42)36-27-14-15-28(26-9-7-6-8-25(26)27)44-20-23-16-17-35-30(18-23)37-32(41)21-43-5/h6-19H,20-21H2,1-5H3,(H,35,37,41)(H2,36,38,42)
SMILES Code
CC(C)(C)C1=NN(C2=CC=C(C)C=C2)C(NC(NC3=C(C=CC=C4)C4=C(OCC5=CC(NC(COC)=O)=NC=C5)C=C3)=O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 592.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Norman P. Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92. doi: 10.1517/13543784.2015.1006358. Epub 2015 Jan 20. PMID: 25599809. 2: Norman P. Respivert's multikinase inhibitors, an evaluation of WO2014033446 to WO2014033449. Expert Opin Ther Pat. 2014 Dec;24(12):1397-407. doi: 10.1517/13543776.2014.967213. PMID: 25407284

View History

NVX-108

NVX-108