Nelonicline citrate | CAS# 1026136-84-4 | Biochemical

MedKoo Cat#: 578056 | Name: Nelonicline citrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nelonicline citrate is an Alpha7 nicotinic acetylcholine receptor agonist and Nicotinic acetylcholine receptor agonist.

Chemical Structure

Nelonicline citrate

CAS#1026136-84-4

Theoretical Analysis

MedKoo Cat#: 578056

Name: Nelonicline citrate

CAS#: 1026136-84-4

Chemical Formula: C23H27N3O8S

Exact Mass: 505.1519

Molecular Weight: 505.54

Elemental Analysis: C, 54.64; H, 5.38; N, 8.31; O, 25.32; S, 6.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Nelonicline citrate

IUPAC/Chemical Name

2-(((3R,4s,5S)-1-azaadamantan-4-yl)oxy)-5-phenyl-1,3,4-thiadiazole 2-hydroxypropane-1,2,3-tricarboxylate

InChi Key

JIGJENFBLHIYGW-KQFFBTLNSA-N

InChi Code

InChI=1S/C17H19N3OS.C6H8O7/c1-2-4-12(5-3-1)16-18-19-17(22-16)21-15-13-6-11-7-14(15)10-20(8-11)9-13;7-3(8)1-6(13,5(11)12)2-4(9)10/h1-5,11,13-15H,6-10H2;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t11?,13-,14+,15-;

SMILES Code

OC(=O)CC(O)(CC(=O)O)C(=O)O.C1C2C[C@H]3CN(C2)C[C@@H]1[C@H]3Oc4nnc(s4)c5ccccc5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 505.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhang D, McGregor M, Bordia T, Perez XA, McIntosh JM, Decker MW, Quik M. α7 nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe nigrostriatal damage. Mov Disord. 2015 Nov 17. doi: 10.1002/mds.26453. [Epub ahead of print] Review. PubMed PMID: 26573698. 2: Hashimoto K. Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker. Curr Pharm Des. 2015;21(26):3797-806. PubMed PMID: 26044974.