MedKoo Cat#: 578043 | Name: NE-10244 hydroxide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NE-10244 hydroxide is a bisphosphonate that has been shown to inhibit tumor cell invasion.

Chemical Structure

NE-10244 hydroxide
NE-10244 hydroxide
CAS#153692-15-0

Theoretical Analysis

MedKoo Cat#: 578043

Name: NE-10244 hydroxide

CAS#: 153692-15-0

Chemical Formula: C9H17NO8P2

Exact Mass: 329.0429

Molecular Weight: 329.18

Elemental Analysis: C, 32.84; H, 5.21; N, 4.26; O, 38.88; P, 18.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
NE 10244 hydroxide; NE10244 hydroxide; NE-10244 hydroxide
IUPAC/Chemical Name
Pyridinium, 3-(3-hydroxy-3,3-diphosphonopropyl)-1-methyl-, hydroxide
InChi Key
VADUXZPJGJBSLQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H15NO7P2.H2O/c1-10-6-2-3-8(7-10)4-5-9(11,18(12,13)14)19(15,16)17;/h2-3,6-7,11H,4-5H2,1H3,(H3-,12,13,14,15,16,17);1H2
SMILES Code
[OH-].C[n+]1cccc(CCC(O)(P(=O)(O)O)P(=O)(O)O)c1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 329.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Boissier S, Ferreras M, Peyruchaud O, Magnetto S, Ebetino FH, Colombel M, Delmas P, Delaissé JM, Clézardin P. Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases. Cancer Res. 2000 Jun 1;60(11):2949-54. PMID: 10850442. 2. Boissier S, Magnetto S, Frappart L, Cuzin B, Ebetino FH, Delmas PD, Clezardin P. Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices. Cancer Res. 1997 Sep 15;57(18):3890-4. PMID: 9307266.