Synonym
Napamezole hydrochloride; Napamezole HCl; Win 51181-2; Win 51,181-2
IUPAC/Chemical Name
2-((3,4-Dihydro-2-naphthyl)methyl)-2-imidazoline hydrochloride
InChi Key
QSIVIHAAKDQDHY-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H16N2.ClH/c1-2-4-13-9-11(5-6-12(13)3-1)10-14-15-7-8-16-14;/h1-4,9H,5-8,10H2,(H,15,16);1H
SMILES Code
Cl.C(C1=Cc2ccccc2CC1)C3=NCCN3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
248.75
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Cordi AA, Berque-Bestel I, Persigand T, Lacoste JM, Newman-Tancredi A, Audinot V, Millan MJ. Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties. J Med Chem. 2001 Mar 1;44(5):787-805. PubMed PMID: 11262089.
2: Perrone MH, Luttinger D, Hamel LT, Fritz PM, Ferraino R, Haubrich DR. In vivo assessment of napamezole, an alpha-2 adrenoceptor antagonist and monoamine re-uptake inhibitor. J Pharmacol Exp Ther. 1990 Aug;254(2):476-83. PubMed PMID: 1974638.
3: Perrone MH, Hamel LT, Ferrari RA, Haubrich DR. Napamezole, an alpha-2 adrenergic receptor antagonist and monoamine uptake inhibitor in vitro. J Pharmacol Exp Ther. 1990 Aug;254(2):471-5. PubMed PMID: 1974637.
4: Wentland MP, Bailey DM, Alexander EJ, Castaldi MJ, Ferrari RA, Haubrich DR, Luttinger DA, Perrone MH. Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives. J Med Chem. 1987 Aug;30(8):1482-9. PubMed PMID: 3039138.
