BP44 is a BET/PARP1 Inhibitor That Induce Defective Homologous Recombination and Lead to Synthetic Lethality for Triple-Negative Breast Cancer Therapy. BP44 shows high selectivity for BRD4 and PARP1. BP44 inhibits the homologous recombination in triplenegative breast cancer (TNBC) and triggers synthetic lethality, thus leading to cell cycle arrest and DNA damage.
MedKoo Cat#: 466184
Name: BP44
CAS#: unknown
Chemical Formula: C25H20N4O4
Exact Mass: 440.1485
Molecular Weight: 440.46
Elemental Analysis: C, 68.17; H, 4.58; N, 12.72; O, 14.53
The following data is based on the product molecular weight 440.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
