Naftopidil dihydrochloride | CAS# 57149-08-3 | Biochemical

MedKoo Cat#: 577933 | Name: Naftopidil dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Naftopidil dihydrochloride is an alpha-1-D adrenoceptor antagonist used to treat dysuria in men with benign prostatic hypertrophy.

Chemical Structure

Naftopidil dihydrochloride

CAS#57149-08-3

Theoretical Analysis

MedKoo Cat#: 577933

Name: Naftopidil dihydrochloride

CAS#: 57149-08-3

Chemical Formula: C24H30Cl2N2O3

Exact Mass: 464.1633

Molecular Weight: 465.41

Elemental Analysis: C, 61.94; H, 6.50; Cl, 15.23; N, 6.02; O, 10.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Naftopidil dihydrochloride; Naftopidil 2HCl

IUPAC/Chemical Name

4-(2-Methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-piperazineethanol dihydrochloride

InChi Key

HZVCEQMJXMUXJF-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H28N2O3.2ClH/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23;;/h2-12,20,27H,13-18H2,1H3;2*1H

SMILES Code

Cl.Cl.COc1ccccc1N2CCN(CC(O)COc3cccc4ccccc34)CC2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 465.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yamamoto M, Shimizu T, Shimizu S, Higashi Y, Nakamura K, Fujieda M, Saito M. Effect of naftopidil on brain noradrenaline-induced decrease in arginine-vasopressin secretion in rats. J Pharmacol Sci. 2016 Sep 8. pii: S1347-8613(16)30117-7. doi: 10.1016/j.jphs.2016.09.002. [Epub ahead of print] PubMed PMID: 27666018. 2: Nakagawa YU, Nagaya H, Miyata T, Wada Y, Oyama T, Gotoh A. Piperazine-based Alpha-1 AR Blocker, Naftopidil, Selectively Suppresses Malignant Human Bladder Cells via Induction of Apoptosis. Anticancer Res. 2016 Apr;36(4):1563-70. PubMed PMID: 27069132. 3: Kohjimoto Y, Hagino K, Ogawa T, Inagaki T, Kitamura S, Nishihata M, Iba A, Matsumura N, Hara I. Naftopidil versus flopropione as medical expulsive therapy for distal ureteral stones: results of a randomized, multicenter, double-blind, controlled trial. World J Urol. 2015 Dec;33(12):2125-9. doi: 10.1007/s00345-015-1556-x. Epub 2015 Apr 14. PubMed PMID: 25869815. 4: Sugaya K, Nishijima S, Kadekawa K, Ashitomi K, Ueda T, Yamamoto H, Hattori T. Action of naftopidil on spinal serotonergic neurotransmission for inhibition of the micturition reflex in rats. Neurourol Urodyn. 2016 Apr 29. doi: 10.1002/nau.23028. [Epub ahead of print] PubMed PMID: 27128660. 5: Matsukawa Y, Funahashi Y, Takai S, Majima T, Ogawa T, Narita H, Kato M, Gotoh M. Comparison of silodosin and naftopidil for efficacy in the treatment of benign prostatic enlargement complicated by overactive bladder: A randomized, prospective study (SNIPER study). J Urol. 2016 Sep 8. pii: S0022-5347(16)31211-3. doi: 10.1016/j.juro.2016.08.111. [Epub ahead of print] PubMed PMID: 27615436. 6: Sugaya K, Nishijima S, Kadekawa K, Ashitomi K, Ueda T, Yamamoto H. Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous congestion. Biomed Res. 2016;37(4):221-6. doi: 10.2220/biomedres.37.221. PubMed PMID: 27544997. 7: Kadekawa K, Sugaya K, Mukoyama H, Sakumoto M, Shimabukuro H, Shimabukuro S, Matayoshi Y, Onaga T, Ashitomi K, Nishijima S. Influence of Naftopidil on Plasma Monoamine Levels and Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia. Low Urin Tract Symptoms. 2016 May;8(2):100-5. doi: 10.1111/luts.12079. Epub 2014 Nov 6. PubMed PMID: 27111621. 8: Peng J, Xiao D, He H, Zhao H, Wang C, Shi T, Shi K. Molecularly imprinted polymeric stir bar: Preparation and application for the determination of naftopidil in plasma and urine samples. J Sep Sci. 2016 Jan;39(2):383-90. doi: 10.1002/jssc.201500751. PubMed PMID: 26541792. 9: Masumori N, Tsukamoto T, Shibuya A, Miyao N, Kunishima Y, Iwasawa A. Three-year outcome analysis of alpha 1-blocker naftopidil for patients with benign prostatic hyperplasia in a prospective multicenter study in Japan. Patient Prefer Adherence. 2016 Jul 22;10:1309-16. doi: 10.2147/PPA.S110440. eCollection 2016. PubMed PMID: 27524886; PubMed Central PMCID: PMC4966686. 10: Tanuma Y, Tanaka Y, Takeyama K, Okamoto T. Does prostate volume affect the efficacy of α1D/A: Adrenoceptor antagonist naftopidil? Urol Ann. 2016 Jan-Mar;8(1):20-5. doi: 10.4103/0974-7796.157979. PubMed PMID: 26834396; PubMed Central PMCID: PMC4719506.