Synonym
CVS-1123; CVS1123; CVS 1123;
IUPAC/Chemical Name
methyl (R)-4-((R)-2-(((S)-5-guanidino-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)-4-oxo-3-(2-propylpentanamido)butanoate
InChi Key
ICMSWQUELAGTTR-IPMKNSEASA-N
InChi Code
InChI=1S/C24H42N6O6/c1-4-8-16(9-5-2)21(33)29-18(14-20(32)36-3)23(35)30-13-7-11-19(30)22(34)28-17(15-31)10-6-12-27-24(25)26/h15-19H,4-14H2,1-3H3,(H,28,34)(H,29,33)(H4,25,26,27)/t17-,18+,19+/m0/s1
SMILES Code
O=C(OC)C[C@@H](NC(C(CCC)CCC)=O)C(N1[C@@H](C(N[C@@H](CCCNC(N)=N)C=O)=O)CCC1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
510.64
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Mendoza CB, Dixon SA, Lods MM, Ma MG, Nguyen KT, Nutt RF, Tran HS, Nolan TG. Quantitation of an orally available thrombin inhibitor in rat, monkey and human plasma and in human urine by high-performance liquid chromatography and fluorescent post-column derivatization of arginine. J Chromatogr A. 1997 Feb 21;762(1-2):299-310. doi: 10.1016/s0021-9673(96)00865-5. PMID: 9098989.
2: Rebello SS, Miller BV, Basler GC, Lucchesi BR. CVS-1123, a direct thrombin inhibitor, prevents occlusive arterial and venous thrombosis in a canine model of vascular injury. J Cardiovasc Pharmacol. 1997 Feb;29(2):240-9. doi: 10.1097/00005344-199702000-00013. PMID: 9057074.
3: Cousins GR, Friedrichs GS, Sudo Y, Rebello SS, Rote WE, Vlasuk GP, Nolan TG, Mendoza C, Lucchesi BR. Orally effective CVS-1123 prevents coronary artery thrombosis in the conscious dog. Circulation. 1996 Oct 1;94(7):1705-12. doi: 10.1161/01.cir.94.7.1705. PMID: 8840864.
