Coumaperine | CAS# 76733-91-0 | Biochemical

MedKoo Cat#: 577909 | Name: Coumaperine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Coumaperine is an NF-kB inhibitor.

Chemical Structure

Coumaperine

CAS#76733-91-0

Theoretical Analysis

MedKoo Cat#: 577909

Name: Coumaperine

CAS#: 76733-91-0

Chemical Formula: C16H19NO2

Exact Mass: 257.1416

Molecular Weight: 257.33

Elemental Analysis: C, 74.68; H, 7.44; N, 5.44; O, 12.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Coumaperine

IUPAC/Chemical Name

N-5-(4-Hydroxyphenyl)-2E,4E-pentadienoyl piperidine

InChi Key

QDAARMDLSCDBFU-YPCIICBESA-N

InChi Code

InChI=1S/C16H19NO2/c18-15-10-8-14(9-11-15)6-2-3-7-16(19)17-12-4-1-5-13-17/h2-3,6-11,18H,1,4-5,12-13H2/b6-2+,7-3+

SMILES Code

Oc1ccc(\C=C\C=C\C(=O)N2CCCCC2)cc1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 257.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Kadosh Y, Muthuraman S, Yaniv K, Baruch Y, Gopas J, Kushmaro A, Kumar RS. Quorum Sensing and NF-κB Inhibition of Synthetic Coumaperine Derivatives from Piper nigrum. Molecules. 2021 Apr 15;26(8):2293. doi: 10.3390/molecules26082293. PMID: 33921056; PMCID: PMC8071387. 2. Nandakumar N, Muthuraman S, Gopinath P, Nithya P, Gopas J, Kumar RS. Synthesis of coumaperine derivatives: Their NF-κB inhibitory effect, inhibition of cell migration and their cytotoxic activity. Eur J Med Chem. 2017 Jan 5;125:1076-1087. doi: 10.1016/j.ejmech.2016.10.047. Epub 2016 Oct 22. PMID: 27810594.