MedKoo Cat#: 466125 | Name: Voa analog 19

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Voa analog 19 is a novel potent VEGFR2 modulator, exhibiting increased antiangiogenic potency than voacangine against VEGF-induced VEGFR2 phosphorylation without cytotoxic effects, resulting in significant tumor cell death in a mouse xenograft model.

Chemical Structure

Voa analog 19
Voa analog 19
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 466125

Name: Voa analog 19

CAS#: unknown

Chemical Formula: C20H21N3O2

Exact Mass: 335.1634

Molecular Weight: 335.41

Elemental Analysis: C, 71.62; H, 6.31; N, 12.53; O, 9.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Voa analog 19; Voa analog-19; Voa-analog 19; Voa-analog-19; V19; V 19; V-19; Voacangine analogue-19; Voacangine-analogue 19; Voacangine analogue 19; Voacangine-analogue-19;
IUPAC/Chemical Name
1-(9-methoxy-3,4,5,6-tetrahydroazepino[4,3-b]indol-2(1H)-yl)-2-(pyridin-2-yl)ethan-1-one
InChi Key
DIKNCSGXNBOYRG-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H21N3O2/c1-25-15-7-8-19-16(12-15)17-13-23(10-4-6-18(17)22-19)20(24)11-14-5-2-3-9-21-14/h2-3,5,7-9,12,22H,4,6,10-11,13H2,1H3
SMILES Code
O=C(N1CC2=C(CCC1)NC3=C2C=C(OC)C=C3)CC4=NC=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 335.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cho SM, Kim Y, Jung Y, Ko M, Marko-Varga G, Kwon HJ. Development of Novel VEGFR2 Inhibitors Originating from Natural Product Analogues with Antiangiogenic Impact. J Med Chem. 2021 Nov 11;64(21):15858-15867. doi: 10.1021/acs.jmedchem.1c01168. Epub 2021 Nov 3. PMID: 34730352.