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MedKoo Cat#: 466122 | Name: GPS491

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GPS491 is a novel HIV replication blocker (EC50 = 0.47 μM), suppressing expression of the HIV-1 structural protein Gag and altered HIV-1 RNA accumulation, decreasing the abundance of RNAs encoding the structural proteins while increasing levels of viral RNAs encoding the regulatory proteins.

Chemical Structure

GPS491
GPS491
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 466122

Name: GPS491

CAS#: unknown

Chemical Formula: C13H5F6N3OS2

Exact Mass: 396.9778

Molecular Weight: 397.31

Elemental Analysis: C, 39.30; H, 1.27; F, 28.69; N, 10.58; O, 4.03; S, 16.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
GPS491; GPS 491; GPS-491;
IUPAC/Chemical Name
5-(trifluoromethyl)-N-(6-(trifluoromethyl)benzo[d]thiazol-2-yl)thiazole-2-carboxamide
InChi Key
DPVVYYGNFLHTFR-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H5F6N3OS2/c14-12(15,16)5-1-2-6-7(3-5)24-11(21-6)22-9(23)10-20-4-8(25-10)13(17,18)19/h1-4H,(H,21,22,23)
SMILES Code
O=C(C1=NC=C(C(F)(F)F)S1)NC2=NC3=C(S2)C=C(C(F)(F)F)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 397.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dahal S, Cheng R, Cheung PK, Been T, Malty R, Geng M, Manianis S, Shkreta L, Jahanshahi S, Toutant J, Chan R, Park S, Brockman MA, Babu M, Mubareka S, Mossman K, Banerjee A, Gray-Owen S, Brown M, Houry WA, Chabot B, Grierson D, Cochrane A. The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation. Viruses. 2021 Dec 30;14(1):60. doi: 10.3390/v14010060. PMID: 35062264; PMCID: PMC8779516. 2: Zamiri M, Cheung PK, Brockman MA, Brumme ZL, Chabot B, Cochrane A, Grierson DS. 2-Trifluoromethylthiazole-5-carboxamides: Analogues of a Stilbene-Based Anti-HIV Agent that Impact HIV mRNA Processing. ACS Med Chem Lett. 2021 Oct 29;12(11):1818-1823. doi: 10.1021/acsmedchemlett.1c00428. PMID: 34795872; PMCID: PMC8591739.