Synonym
KT2-962; KT2962; KT2 962;
IUPAC/Chemical Name
sodium 3-(4-((4-chlorophenyl)sulfonamido)butyl)-6-isopropylazulene-1-sulfonate
InChi Key
QIBQVFYOTMPEIP-UHFFFAOYSA-M
InChi Code
InChI=1S/C23H26ClNO5S2.Na/c1-16(2)17-6-12-21-18(15-23(32(28,29)30)22(21)13-7-17)5-3-4-14-25-31(26,27)20-10-8-19(24)9-11-20;/h6-13,15-16,25H,3-5,14H2,1-2H3,(H,28,29,30);/q;+1/p-1
SMILES Code
O=S(C1=C2C=CC(C(C)C)=CC=C2C(CCCCNS(=O)(C3=CC=C(Cl)C=C3)=O)=C1)([O-])=O.[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
518.01
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Nagao T, Koseki J, Suzuki Y, Nagamatsu T. Thromboxane A(2) causes retarded clearance of aggregated protein in glomeruli of nephritic mice. Eur J Pharmacol. 2001 Feb 16;413(2-3):271-9. doi: 10.1016/s0014-2999(00)00932-8. PMID: 11226403.
3: Yokota M, Uchibori S, Hayashi H, Koyama R, Kosakai K, Wakabayashi S, Tomiyama T. Azulene derivatives as TXA2/PGH2 receptor antagonists--II. Synthesis and biological activity of 6-mono- and 6-dihydroxylated-isopropylazulenes. Bioorg Med Chem. 1996 Apr;4(4):575-91. doi: 10.1016/0968-0896(96)00038-7. PMID: 8735846.
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5: Enzan K, Komatsu H, Shoji K, Suzuki M. [Effects of thromboxane on pulmonary arterial response to platelet activating factor in rabbit]. Masui. 1995 May;44(5):633-42. Japanese. PMID: 7609288.
6: Shoji K, Enzan K, Masaki Y, Suzuki M, Yoshioka N. [Effects of thromboxane A2 receptor antagonist, KT2-962 on pulmonary hypertensive responses to antigen challenge in isolated sensitized rabbit lung]. Masui. 1995 Jan;44(1):21-5. Japanese. PMID: 7699820.
7: Kosakai K, Wakabayashi S, Sato T, Mochizuki S, Tomiyama A, Zhou Q, Satake N, Shibata S. Pharmacologic properties of KT2-962 (6-isopropyl-3-[4-(p- chlorobenzenesulfonylamino)-butyl]-azulene-1-sulfonic acid sodium salt); a new TXA2/prostaglandin endoperoxide receptor antagonist. J Cardiovasc Pharmacol. 1993 Mar;21(3):441-7. doi: 10.1097/00005344-199303000-00014. PMID: 7681506.
