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MedKoo Cat#: 471143 | Name: Agrimol B
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Agrimol B is a polyphenol with adipogenesis inhibitory and anticancer activities.

Chemical Structure

Agrimol B
CAS#55576-66-4

Theoretical Analysis

MedKoo Cat#: 471143

Name: Agrimol B

CAS#: 55576-66-4

Chemical Formula: C37H46O12

Exact Mass: 682.2990

Molecular Weight: 682.76

Elemental Analysis: C, 65.09; H, 6.79; O, 28.12

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
Agrimol B;
IUPAC/Chemical Name
(S)-1,1'-(((2,4,6-trihydroxy-5-(2-methylbutanoyl)-1,3-phenylene)bis(methylene))bis(2,4-dihydroxy-6-methoxy-5-methyl-3,1-phenylene))bis(butan-1-one)
InChi Key
BVLHMPZMQVWDGX-INIZCTEOSA-N
InChi Code
InChI=1S/C37H46O12/c1-9-12-23(38)25-32(44)19(29(41)17(5)36(25)48-7)14-21-31(43)22(35(47)27(34(21)46)28(40)16(4)11-3)15-20-30(42)18(6)37(49-8)26(33(20)45)24(39)13-10-2/h16,41-47H,9-15H2,1-8H3/t16-/m0/s1
SMILES Code
CC[C@H](C)C(C1=C(O)C(CC2=C(O)C(C(CCC)=O)=C(OC)C(C)=C2O)=C(O)C(CC3=C(O)C(C(CCC)=O)=C(OC)C(C)=C3O)=C1O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 682.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang S, Zhang Q, Zhang Y, Shen C, Wang Z, Wu Q, Zhang Y, Li S, Qiao Y. Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway. Biochem Biophys Res Commun. 2016 Aug 26;477(3):454-60. doi: 10.1016/j.bbrc.2016.06.078. Epub 2016 Jun 16. PMID: 27320865. 2: Xiang D, Yang W, Fang Z, Mao J, Yan Q, Li L, Tan J, Yu C, Qian J, Tang D, Pan X, Cheng H, Sun D. Agrimol B inhibits colon carcinoma progression by blocking mitochondrial function through the PGC-1α/NRF1/TFAM signaling pathway. Front Oncol. 2022 Dec 14;12:1055126. doi: 10.3389/fonc.2022.1055126. PMID: 36591497; PMCID: PMC9794846. 3: Hnit SST, Ding R, Bi L, Xie C, Yao M, De Souza P, Xu L, Li Z, Dong Q. Agrimol B present in Agrimonia pilosa Ledeb impedes cell cycle progression of cancer cells through G0 state arrest. Biomed Pharmacother. 2021 Sep;141:111795. doi: 10.1016/j.biopha.2021.111795. Epub 2021 Jun 4. PMID: 34098217. 4: Wang Z, Liu P, Liang P, Hu X. Development of a liquid chromatography-mass spectrometry method for determination of agrimol B in rat plasma: application to preclinical pharmacokinetics. Biomed Chromatogr. 2015 Apr;29(4):481-4. doi: 10.1002/bmc.3299. Epub 2014 Jul 26. PMID: 25065576. 5: Zhai X, Li L, Zhang P, Guo Y, Jiang H, He W, Li Y, Zhang B, Yao D. EVALUATION OF THE INHIBITORY EFFECTS OF SIX NATURAL PRODUCT EXTRACTS AGAINST BABESIA GIBSONI IN VITRO AND IN VIVO. J Parasitol. 2022 Jul 1;108(4):301-305. doi: 10.1645/21-108. PMID: 35877154. 6: Pei YH, Li X, Zhu TR. [Studies on the chemical constituents from the root- sprouts of Agrimonia pilosa Ledeb]. Yao Xue Xue Bao. 1989;24(6):431-7. Chinese. PMID: 2609982. 7: Barac R, Als D, Radhakrishnan A, Gaffey MF, Bhutta ZA, Barwick M. Implementation of Interventions for the Control of Typhoid Fever in Low- and Middle-Income Countries. Am J Trop Med Hyg. 2018 Sep;99(3_Suppl):79-88. doi: 10.4269/ajtmh.18-0110. Epub 2018 Jul 24. PMID: 30047365; PMCID: PMC6128369.